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Home - Products - Metabolic Enzyme/Protease - Dehydrogenase - MF-438

MF-438

CAS No. 921605-87-0

MF-438( —— )

Catalog No. M22502 CAS No. 921605-87-0

MF-438 is an effective and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor (EC50: 2.3 nM for rSCD1). In a mouse model, MF-438 shows an ED50 between 1 and 3 mg/kg.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 132 In Stock
5MG 203 In Stock
10MG 311 In Stock
25MG 527 In Stock
50MG 754 In Stock
100MG 1044 In Stock
500MG 2088 In Stock
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Biological Information

  • Product Name
    MF-438
  • Note
    Research use only, not for human use.
  • Brief Description
    MF-438 is an effective and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor (EC50: 2.3 nM for rSCD1). In a mouse model, MF-438 shows an ED50 between 1 and 3 mg/kg.
  • Description
    MF-438 is an effective and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor (EC50: 2.3 nM for rSCD1). In a mouse model, MF-438 shows an ED50 between 1 and 3 mg/kg.
  • In Vitro
    ——
  • In Vivo
    MF-438 exhibits an ED50 between 1 and 3 mg/kg in a mouse model.
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Dehydrogenase
  • Recptor
    SCD
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    921605-87-0
  • Formula Weight
    421.44
  • Molecular Formula
    C19H18F3N5OS
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:62.5 mg/mL (148.30 mM; Need ultrasonic)
  • SMILES
    Cc1nnc(s1)-c1ccc(nn1)N1CCC(CC1)Oc1ccccc1C(F)(F)F
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Léger S, et al. Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438). Bioorg Med Chem Lett. 2010 Jan 15;20(2):499-502.
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