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Home - Products - Metabolic Enzyme/Protease - Dehydrogenase - DHODH-IN-13

DHODH-IN-13

CAS No. 1364791-86-5

DHODH-IN-13( —— )

Catalog No. M26154 CAS No. 1364791-86-5

DHODH-IN-13 is the hydroxyfuran analogue of A771726.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    DHODH-IN-13
  • Note
    Research use only, not for human use.
  • Brief Description
    DHODH-IN-13 is the hydroxyfuran analogue of A771726.
  • Description
    DHODH-IN-13 is the hydroxyfuran analogue of A771726. DHODH-IN-13 is a dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 4.3 μM for rat liver DHODH. DHODH-IN-13 can be used for rheumatoid arthritis.
  • In Vitro
    DHODH-IN-13 (Compound 7a) is a hydroxyfurazan analog of A771726 and is stable under physiological conditions. When DHODH-IN-13 is docked in silico at the DHODH active site, a BQN-like pose is obtained with the deprotonated furazan hydroxyl facing Arg136 instead of Tyr356, thus effectively mimicking the carboxyl group of BQN and related compounds.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Dehydrogenase
  • Recptor
    E3 Ligase Ligand-Linker Conjugate
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1364791-86-5
  • Formula Weight
    273.171
  • Molecular Formula
    C10H6F3N3O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    FC(F)(F)c1ccc(NC(=O)c2no[nH]c2=O)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.
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