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DB2313
CAS No. 2170606-74-1
DB2313 ( Carboximidamide )
Catalog No. M28847 CAS No. 2170606-74-1
DB2313 is a potent transcription factor PU.1 inhibitor, IC50=14 nM. DB2313 disrupts the interaction of PU.1 with target gene promoters. DB2313 induces apoptosis of acute myeloid leukemia (AML) cells, and has anticancer effects
Purity : >98% (HPLC)
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Size | Price / USD | Stock | Quantity |
5MG | 110 | Get Quote |
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10MG | 177 | Get Quote |
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25MG | 410 | Get Quote |
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50MG | 605 | Get Quote |
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100MG | Get Quote | Get Quote |
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200MG | Get Quote | Get Quote |
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500MG | Get Quote | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NameDB2313
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NoteResearch use only, not for human use.
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Brief DescriptionDB2313 is a potent transcription factor PU.1 inhibitor, IC50=14 nM. DB2313 disrupts the interaction of PU.1 with target gene promoters. DB2313 induces apoptosis of acute myeloid leukemia (AML) cells, and has anticancer effects
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DescriptionDB2313 is a potent transcription factor PU.1 inhibitor, IC50=14 nM. DB2313 disrupts the interaction of PU.1 with target gene promoters. DB2313 induces apoptosis of acute myeloid leukemia (AML) cells, and has anticancer effects(In Vitro):DB2313 decreases PU.1 occupancy on E2f1, Junb, and Csf1r promoters in AML cells. DB2313 treatment leads to a profound decrease in the growth of PU.1 URE–/– acute myeloid leukemia (AML) cells (IC50 of 7.1 μM), while showing little effect on normal hematopoietic cells at similar concentrations. DB2313 treatment leads to a 3.5-fold increase in apoptotic cells in murine PU.1 URE–/– AML cells. DB2313 also leads to a significant decrease in clonogenicity in the second and third rounds of plating and a complete disruption of clonogenic capacity in the fourth and higher rounds of plating. (In Vivo):DB2313 (17 mg/kg; i.p.; three times per week for 3 weeks) treatment decreases leukemia progression and results in increased survival in mice.
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SynonymsCarboximidamide
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PathwayApoptosis
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TargetApoptosis
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Recptor5-HT2C;5-HT2A;5-HT2B
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Research Area——
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Indication——
Chemical Information
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CAS Number2170606-74-1
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Formula Weight708.8
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Molecular FormulaC42H41FN8O2
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Porter RH,et al. Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells.Br J Pharmacol. 1999 Sep;128(1):13-20.
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