DAMGO( —— )

Catalog No. M17594 CAS No. 78123-71-4

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

DAMGO
Note

Research use only, not for human use.
Brief Description

DAMGO is an opioid receptor agonist with the ability to affect the locomotive activity in rodents. Possible analgesic agent due to μ-opiod receptor interaction.
Description

DAMGO is an opioid receptor agonist with the ability to affect the locomotive activity in rodents. Possible analgesic agent due to μ-opiod receptor interaction.
In Vitro

DAMGO (1-10 μM) significantly reduces the activation of neuronal Akt and ERK1/2 by CXCL12 and inhibits CXCL12-promoted neuronal survival, but does not down-regulate CXCR4 protein expression. DAMGO (1 μM) effectively inhibits the prostaglandin E 2 (PGE 2) induced increase in a tetrodotoxin-resistant voltage-gated Na+ current (TTX-R I Na), i.e. PGE 2 (1 μM) can increase the TTX-R I Na peak by 103 % compared to 24.9 % with the addition of DAMGO.
In Vivo

DAMGO (i.v., 0.5-2 mg/kg) can produce significant anti-injury effects on injured paws of male Sprague-Dawley rats weighing 200-225 g in a dose-dependent manner, producing an effective and long-lasting analgesic effect.
Synonyms

——
Pathway

MAPK/ERK Signaling
Target

p38 MAPK
Recptor

μ-opioid receptor
Research Area

——
Indication

——

CAS Number

78123-71-4
Formula Weight

513.6
Molecular Formula

C26H35N5O6
Purity

>98% (HPLC)
Solubility

DMSO : 33.33 mg/mL. 64.90 mM;
SMILES

Oc2ccc(C[C@H](N)C(=O)N[C@H](C)C(=O)NCC(=O)N(C)[C@@H](Cc1ccccc1)C(=O)NCCO)cc2
Chemical Name

——

1. Zhang W, etal. Neuroscience, 2015, 301: 144-154.

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