D77 ( D-77 )

Catalog No. M14665 CAS No. 497836-10-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

D77
Note

Research use only, not for human use.
Brief Description

A potent inhibitor of HIV-1 integrase-LEDGF/p75 interaction; binds to IN and IN(T125A) with Kd of 5.81 and 15.2 uM.
Description

A potent inhibitor of HIV-1 integrase-LEDGF/p75 interaction; binds to IN and IN(T125A) with Kd of 5.81 and 15.2 uM; affects the HIV-1 IN nuclear distribution thus exhibiting antiretroviral activity.HIV Infection Preclinical
Synonyms

D-77
Pathway

Microbiology/Virology
Target

HIV
Recptor

HIV
Research Area

Infection
Indication

HIV Infection

CAS Number

497836-10-9
Formula Weight

596.45
Molecular Formula

C28H22BrNO7S
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

O=C(O)C1=CC=C(COC2=CC(Br)=C(/C=C(SC(N3CC(C4=CC=CC=C4)=O)=O)/C3=O)C=C2OCC)C=C1
Chemical Name

Benzoic acid, 4-[[5-bromo-4-[[2,4-dioxo-3-(2-oxo-2-phenylethyl)-5-thiazolidinylidene]methyl]-2-ethoxyphenoxy]methyl]-

1. Du L, et al. Biochem Biophys Res Commun. 2008 Oct 10;375(1):139-44.
2. Li P, et al. J Biomol Struct Dyn. 2011 Oct;29(2):311-23.

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