Cycleanine

CAS No. 518-94-5

Cycleanine( —— )

Catalog No. M21511 CAS No. 518-94-5

Cycleanine has potent antibacterial antifungal antiplasmodial and cytotoxic activities.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Cycleanine
  • Note
    Research use only, not for human use.
  • Brief Description
    Cycleanine has potent antibacterial antifungal antiplasmodial and cytotoxic activities.
  • Description
    Cycleanine has potent antibacterial antifungal antiplasmodial and cytotoxic activities.
  • In Vitro
    Cycleanine inhibits L-type Ca-current (ICaL) of single rat ventricular cardiomyocytes in a voltage- and frequency-dependent manner.Cycleanine shows modestly less potency against human OSE cells (normal) than the cancer cells.Cycleanine (20 μM; 48 hours) exhibits cytotoxicity for Ovcar-8, A2780, Igrov-1, and Ovcar-4 cell lines with IC50s ranging from 7 to 14 μM.Cycleanine (20 μM; 24 hours) results in significant PARP cleavage (a marker of apoptosis).Cycleanine (20 μM; 48 hours) causes a significant increase of the population of both early and late apoptotic cells. Cell Cytotoxicity AssayCell Line:Ovcar-8 cells, A2780 cells, Igrov-1 cells, Ovcar-4 cellsConcentration:20 μM Incubation Time:48 hoursResult:Exhibited cytotoxicity for Ovcar-8, A2780, Igrov-1, and Ovcar-4 cell lines with IC50 values of 10 μM, 7.6 μM, 14 μM, 7.2 μM, respectively.Western Blot Analysis Cell Line:Ovcar-8 cells Concentration:20 μM Incubation Time:24 hours Result:Induced 1.1-fold increase in PARP-1 cleavage compared with carboplatin.Apoptosis Analysis Cell Line:Ovcar-8 cells Concentration:20 μM Incubation Time:48 hours Result:Caused a significant increase of the population of both early and late apoptotic cells.Cell Cycle Analysis Cell Line:Ovcar-8 cells Concentration:20 μM Incubation Time:48 hours Result:Increased the percentage of Ovcar-8 cells in subG1.
  • In Vivo
    Cycleanine inhibits the KCl-induced contraction of rabbit aortic rings with an IC50 of 0.8 nM.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    518-94-5
  • Formula Weight
    622.7
  • Molecular Formula
    C38H42N2O6
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 5 mg/mL (8.03 mM)
  • SMILES
    [H][C@]12Cc3ccc(Oc4c(OC)c(OC)cc5CCN(C)[C@]([H])(Cc6ccc(Oc7c(OC)c(OC)cc(CCN1C)c27)cc6)c45)cc3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.M-L Lohombo-Ekomba et al. Antibacterial Antifungal Antiplasmodial and Cytotoxic Activities of Albertisia Villosa. J Ethnopharmacol. 2004 Aug;93(2-3):331-5.
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