Cosmosiin( Apigetrin )

Catalog No. M18842 CAS No. 578-74-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

Cosmosiin
Note

Research use only, not for human use.
Brief Description

Cosmosiin may be beneficial for diabetic complications through their enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and GLUT4 translocation.
Description

Apigetrin is a flavanoid derivved from dandelions which may inhibit neuroinflammation in BV-2 microglia and have a neuroprotective effect in HT22 hippocampal cells. This molecule may also hinder cancer progression by inhibiting various pathways such as STAT3/JAK2.
In Vitro

Apigenin 7-glucoside exhibits significant anti-proliferative activity against B16F10 melanoma cells after 24 and 48 h of incubation. Apigenin-7-glucosideprovoks an increase of subG0/G1, S and G2/M phase cell proportion with a significant decrease of cell proportion in G0/G1 phases. Apigenin-7-glucosideenhances melanogenesis synthesis and tyrosinase activity of B16F10 melanoma cells.Apigenin 7-glucoside specifically induces the differentiation of CD34+ cells towards the erythroid lineage and inhibited the myeloid differentiation. Apigenin 7-glucoside has strong antioxidant activity against reactive oxygen species (ROS) in vitro in a concentration-dependent manner.
In Vivo

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Synonyms

Apigetrin
Pathway

Others
Target

Antioxidant
Recptor

HIV
Research Area

Others-Field
Indication

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CAS Number

578-74-5
Formula Weight

432.38
Molecular Formula

C21H20O10
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 30 mg/mL; 69.38 mM
SMILES

C1=CC(=CC=C1C2=CC(=O)C3=C(C=C(C=C3O2)OC4C(C(C(C(O4)CO)O)O)O)O)O
Chemical Name

7-(beta-D-Glucopyranosyloxy)-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one