
Cosalane
CAS No. 154212-56-3
Cosalane( —— )
Catalog No. M33975 CAS No. 154212-56-3
Cosalane (NSC 658586) is an HIV replication inhibitor, an inhibitor of chemokine receptor 7 (CCR7) signalling in humans and mice, with antiviral activity that blocks the binding of CCR7 to its natural ligands, CCL19 and CCL21.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
2MG | 702 | Get Quote |
![]() ![]() |
5MG | 1017 | Get Quote |
![]() ![]() |
10MG | 1254 | Get Quote |
![]() ![]() |
25MG | 1610 | Get Quote |
![]() ![]() |
50MG | 2006 | Get Quote |
![]() ![]() |
500MG | Get Quote | Get Quote |
![]() ![]() |
1G | Get Quote | Get Quote |
![]() ![]() |
Biological Information
-
Product NameCosalane
-
NoteResearch use only, not for human use.
-
Brief DescriptionCosalane (NSC 658586) is an HIV replication inhibitor, an inhibitor of chemokine receptor 7 (CCR7) signalling in humans and mice, with antiviral activity that blocks the binding of CCR7 to its natural ligands, CCL19 and CCL21.
-
DescriptionCosalane (NSC 658586) is a potent inhibitor of HIV replication. Cosalane has an intrinsic ability to block human and murine CCR7 function in vitro in response to both of its natural ligands, CCL19 and CCL21, with the IC50 of 0.207/2.66 μM in human for CCL19/CCL21 and 0.193/1.98 μM in murine, respectively.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayMicrobiology/Virology
-
TargetHIV
-
RecptorHIV Protease
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number154212-56-3
-
Formula Weight767.86
-
Molecular FormulaC45H60Cl2O6
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESC[C@@]12[C@@]3([C@]([C@]4([C@](C)(CC3)[C@@]([C@@H](CCCC(C)C)C)(CC4)[H])[H])(CC[C@]1(C[C@@H](CCC=C(C5=CC(C(O)=O)=C(O)C(Cl)=C5)C6=CC(C(O)=O)=C(O)C(Cl)=C6)CC2)[H])[H])[H]
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Kenneth A Fowler, et al. The Ex Vivo Treatment of Donor T Cells with Cosalane, an HIV Therapeutic and Small-Molecule Antagonist of CC-Chemokine Receptor 7, Separates Acute Graft-versus-Host Disease from Graft-versus-Leukemia Responses in Murine Hematopoietic Stem Cell Transplantation Models. Biol Blood Marrow Transplant. 2019 Jun;25(6):1062-1074.?
molnova catalog



related products
-
Isoxanthohumol
Isoxanthohumol shows an antiviral activity towards herpes viruses (HSV1 and HSV2) and bovine viral diarrhea virus (BVDV).
-
14-Dicaffeoylquinic ...
14-Dicaffeoylquinic acid has antioxidant activity.14-Dicaffeoylquinic acid is a potent and highly selective class of HIV-1 integrase inhibitors inhibitsHIV-1 replication in MT-2 cell culture at non-toxic concentrations.
-
I-XW-053
I-XW-053 is an inhibitor of capsid targeted HIV-1 replication using the hybrid structure based method to block the interface between CA N-terminal domains (NTD-NTD interface) with micromolar affinity.