Clemizole
CAS No. 442-52-4
Clemizole ( Clemizole; NSC 46261; NSC-46261; NSC46261 )
Catalog No. M14505 CAS No. 442-52-4
An H1 histamine receptor antagonist that substantially inhibits HCV replication by suppression of NS4B's RNA binding (IC50=24 nM) with little toxicity for the host cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 71 | In Stock |
|
10MG | 97 | In Stock |
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25MG | 147 | In Stock |
|
50MG | 257 | In Stock |
|
100MG | 461 | In Stock |
|
500MG | 972 | In Stock |
|
1G | Get Quote | In Stock |
|
Biological Information
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Product NameClemizole
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NoteResearch use only, not for human use.
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Brief DescriptionAn H1 histamine receptor antagonist that substantially inhibits HCV replication by suppression of NS4B's RNA binding (IC50=24 nM) with little toxicity for the host cells.
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DescriptionAn H1 histamine receptor antagonist that substantially inhibits HCV replication by suppression of NS4B's RNA binding (IC50=24 nM) with little toxicity for the host cells; also selectively and efficiently blocks TRPC5 currents and Ca(2+) entry with IC50 of 1-1.3 uM, 6-fold selectivity over TRPC4β (IC50 = 6.4 μM), and almost 10-fold selectivity over TRPC3 (IC50 =9.1 uM) and TRPC6 (IC50=11.3 uM), only very weakly affects TRPM3, TRPM8 and TRPV1, V2, V3, and V4 channels. HCV Infection Phase 2 Clinical
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SynonymsClemizole; NSC 46261; NSC-46261; NSC46261
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PathwayMembrane Transporter/Ion Channel
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TargetTRP/TRPV Channel
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RecptorNS4BH1histaminereceptor
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Research AreaInfection
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IndicationHCV Infection
Chemical Information
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CAS Number442-52-4
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Formula Weight325.84
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Molecular FormulaC19H20ClN3
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESClC1=CC=C(C=C1)CN2C3=CC=CC=C3N=C2CN4CCCC4
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Chemical Name1H-Benzimidazole, 1-[(4-chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Richter JM, et al. Mol Pharmacol. 2014 Nov;86(5):514-21.
2. Einav S, et al. Nat Biotechnol. 2008 Sep;26(9):1019-27.
3. Einav S, et al. J Infect Dis. 2010 Jul 1;202(1):65-74.
2. Einav S, et al. Nat Biotechnol. 2008 Sep;26(9):1019-27.
3. Einav S, et al. J Infect Dis. 2010 Jul 1;202(1):65-74.
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