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AMG-517

CAS No. 659730-32-2

AMG-517 ( AMG-517; AMG 517; AMG517; BD-0082 )

Catalog No. M15510 CAS No. 659730-32-2

AMG 517 is a potent and selective TRPV1 antagonist, antagonizes capsaicin, proton, and heat activation of TRPV1 with IC50 of 0.76 nM, 0.62 nM and 1.3 nM.

Purity : >98%(HPLC)

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Biological Information

  • Product Name
    AMG-517
  • Note
    Research use only, not for human use.
  • Brief Description
    AMG 517 is a potent and selective TRPV1 antagonist, antagonizes capsaicin, proton, and heat activation of TRPV1 with IC50 of 0.76 nM, 0.62 nM and 1.3 nM.
  • Description
    AMG 517 is a potent and selective TRPV1 antagonist, antagonizes capsaicin, proton, and heat activation of TRPV1 with IC50 of 0.76 nM, 0.62 nM and 1.3 nM.
  • Synonyms
    AMG-517; AMG 517; AMG517; BD-0082
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    TRP/TRPV Channel
  • Recptor
    TRPV1
  • Research Area
    Neurological Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    659730-32-2
  • Formula Weight
    430.40
  • Molecular Formula
    C20H13F3N4O2S
  • Purity
    >98%(HPLC)
  • Solubility
    DMSO:86 mg/mL (199.81 mM)Ethanol:<1 mg/mL (<1 mM)Water:<1 mg/mL (<1 mM)
  • SMILES
    CC(NC1=NC2=C(OC3=NC=NC(C4=CC=C(C(F)(F)F)C=C4)=C3)C=CC=C2S1)=O
  • Chemical Name
    Acetamide, N-(4-((6-(4-(trifluoromethyl)phenyl)-4-pyrimidinyl)oxy)-2-benzothiazolyl)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Gavva NR, et al. J Pharmacol Exp Ther, 2007, 323(1), 128-137.
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