AMG-517 ( AMG-517; AMG 517; AMG517; BD-0082 )

Catalog No. M15510 CAS No. 659730-32-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

AMG-517
Note

Research use only, not for human use.
Brief Description

AMG 517 is a potent and selective TRPV1 antagonist, antagonizes capsaicin, proton, and heat activation of TRPV1 with IC50 of 0.76 nM, 0.62 nM and 1.3 nM.
Description

AMG 517 is a potent and selective TRPV1 antagonist, antagonizes capsaicin, proton, and heat activation of TRPV1 with IC50 of 0.76 nM, 0.62 nM and 1.3 nM.
Synonyms

AMG-517; AMG 517; AMG517; BD-0082
Pathway

Membrane Transporter/Ion Channel
Target

TRP/TRPV Channel
Recptor

TRPV1
Research Area

Neurological Disease
Indication

——

CAS Number

659730-32-2
Formula Weight

430.40
Molecular Formula

C20H13F3N4O2S
Purity

>98%(HPLC)
Solubility

DMSO:86 mg/mL (199.81 mM)Ethanol:<1 mg/mL (<1 mM)Water:<1 mg/mL (<1 mM)
SMILES

CC(NC1=NC2=C(OC3=NC=NC(C4=CC=C(C(F)(F)F)C=C4)=C3)C=CC=C2S1)=O
Chemical Name

Acetamide, N-(4-((6-(4-(trifluoromethyl)phenyl)-4-pyrimidinyl)oxy)-2-benzothiazolyl)-

1. Gavva NR, et al. J Pharmacol Exp Ther, 2007, 323(1), 128-137.

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