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Cilomilast
CAS No. 153259-65-5
Cilomilast ( SB-207499;SB207499;SB 207499 )
Catalog No. M12158 CAS No. 153259-65-5
A potent and selective PDE4 inhibitor with IC50 of 95/120 nM for LPDE4/HPDE4.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 41 | In Stock |
|
| 5MG | 74 | In Stock |
|
| 10MG | 133 | In Stock |
|
| 25MG | 241 | In Stock |
|
| 50MG | 429 | In Stock |
|
| 100MG | 628 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCilomilast
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and selective PDE4 inhibitor with IC50 of 95/120 nM for LPDE4/HPDE4.
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DescriptionA potent and selective PDE4 inhibitor with IC50 of 95/120 nM for LPDE4/HPDE4; shows selectivity for PDE4 over the other PDE isozymes and is 75-fold more selective than (R)-rolipram with respect to LPDE4 activity versus HPDE4 activity; inhibits antigen-induced bronchoconstriction in conscious guinea pigs at 30 mg/kg and orally acitive.COPD Phase 3 Discontinued
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SynonymsSB-207499;SB207499;SB 207499
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PathwayAngiogenesis
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TargetPDE
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RecptorHPDE4;LPDE4
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Research AreaInflammation/Immunology
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IndicationCOPD
Chemical Information
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CAS Number153259-65-5
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Formula Weight343.42
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Molecular FormulaC20H25NO4
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C([C@H]1CC[C@](C2=CC=C(OC)C(OC3CCCC3)=C2)(C#N)CC1)O
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Chemical NameCyclohexanecarboxylic acid, 4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]-, cis-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Christensen SB, et al. J Med Chem. 1998 Mar 12;41(6):821-35.
2. Barnette MS, et al. J Pharmacol Exp Ther. 1998 Jan;284(1):420-6.
3. Griswold DE, et al. J Pharmacol Exp Ther. 1998 Nov;287(2):705-11.
2. Barnette MS, et al. J Pharmacol Exp Ther. 1998 Jan;284(1):420-6.
3. Griswold DE, et al. J Pharmacol Exp Ther. 1998 Nov;287(2):705-11.
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