Chymase-IN-1

CAS No. 862090-74-2

Chymase-IN-1 ( —— )

Catalog No. M26114 CAS No. 862090-74-2

Chymase-IN-1 is a selective, orally active inhibitor of human mast cell chymase (IC50: 29 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 583 Get Quote
10MG 830 Get Quote
25MG 1242 Get Quote
50MG 1674 Get Quote
100MG 2241 Get Quote
500MG 4437 Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    Chymase-IN-1
  • Note
    Research use only, not for human use.
  • Brief Description
    Chymase-IN-1 is a selective, orally active inhibitor of human mast cell chymase (IC50: 29 nM).
  • Description
    Chymase-IN-1 is a selective, orally active inhibitor of human mast cell chymase (IC50: 29 nM).(In Vitro):Chymase-IN-1 (compound 5f) has a chymase Ki value of 36 nM and a Cat G Ki value of 9500 nM.(In Vivo):Chymase-IN-1 shows low oral bioavailability in rats (F=3%; oral t1/2=1.8 h).
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Akt; Angiotensin Receptor; PI3K; β-adrenoceptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    862090-74-2
  • Formula Weight
    431.8
  • Molecular Formula
    C20H15ClNO4PS
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    OP(O)(=O)C(C(=O)Nc1ccc2ccccc2c1)c1csc2ccc(Cl)cc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Sun JJ, Kim HJ, Seo HG, et al. YS49,1-(alpha-naphtylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline,regulates angiotensin II-stimulated ROS production, JNK phosphorylation and vascular smooth muscle cell proliferation via the induction of heme oxygenase-1. Life Sci. 2008;82(11-12):600-7.
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