Centrinone-B( —— )

Catalog No. M33313 CAS No. 1798871-31-4

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Centrinone-B
Note

Research use only, not for human use.
Brief Description

Centrinone-B (LCR-323) is a potent and highly selective PLK4 inhibitor with a Ki of 0.59 nM.
Description

Centrinone-B (LCR-323) is a potent and highly selective PLK4 inhibitor, with a Ki of 0.59 nM.
In Vitro

Centrinone-B (LCR-323) is a potent and highly selective PLK4 inhibitor, with a Ki of 0.59 nM. Centrinone-B slightly binds to Aurora A and Aurora B, with Kis of 1239 nM and 5597.14 nM. Centrinone-B (LCR-323) exhibits >1000-fold selectivity for Plk4 over Aurora A/B in vitro and does not affect cellular Aurora A or B substrate phosphorylation at concentrations that deplete centrosomes. Centrinone-B (LCR-323) (0-200 nM) significantly decreases cell viability of PLK4-centriole conjunction melanoma cell lines except p53 mutant SK-MEL-28, and this effect is via inhibition of PLK4. Inhibition of PLK4 by Centrinone-B (LCR-323) also induces apoptosis in human melanoma cell lines.
In Vivo

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Synonyms

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Pathway

Cell Cycle/DNA Damage
Target

PLK
Recptor

PLK
Research Area

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Indication

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CAS Number

1798871-31-4
Formula Weight

631.67
Molecular Formula

C27H27F2N7O5S2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 25 mg/mL (39.58 mM; Ultrasonic )
SMILES

COc1c(Nc2cc(C)[nH]n2)nc(Sc2ccc(cc2F)S(=O)(=O)Cc2cccc(c2F)[N+]([O-])=O)nc1N1CCCCC1
Chemical Name

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1. Wong YL, et al. Cell biology. Reversible centriole depletion with an inhibitor of Polo-like kinase 4. Science. 2015 Jun 5;348(6239):1155-60.?

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