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Celastrol

CAS No. 34157-83-0

Celastrol( Tripterin )

Catalog No. M14158 CAS No. 34157-83-0

Celastrol (Tripterin) is an active compound extracted from Chinese medicine Thunder of God Vine.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Celastrol
  • Note
    Research use only, not for human use.
  • Brief Description
    Celastrol (Tripterin) is an active compound extracted from Chinese medicine Thunder of God Vine.
  • Description
    Celastrol (Tripterin) is an active compound extracted from Chinese medicine Thunder of God Vine, is a potent proteasome inhibitor, preferentially inhibits the chymotrypsin-like activity of 20S proteasome with IC50 of 2.5 uM; also inhibits 26S proteasome in intact androgen-independent PC-3 and androgen-dependent LNCaP prostate cancer cells at 1-5 uM, induces apoptotic cell death, and accumulates ubiquitinated proteins and natural proteasome substrates, IκB-α, Bax, and p27, and/or suppression of AR protein expression; promotes significant tumor growth inhibition and massive apoptosis induction in vivo.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Tripterin
  • Pathway
    Proteasome/Ubiquitin
  • Target
    Proteasome
  • Recptor
    20Sproteasome
  • Research Area
    Inflammation/Immunology
  • Indication
    ——

Chemical Information

  • CAS Number
    34157-83-0
  • Formula Weight
    450.6096
  • Molecular Formula
    C29H38O4
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    CC1=C(C(=O)C=C2C1=CC=C3C2(CCC4(C3(CCC5(C4CC(CC5)(C)C(=O)O)C)C)C)C)O
  • Chemical Name
    24,25,26-Trinoroleana-1(10),3,5,7-tetraen-29-oic acid, 3-hydroxy-9,13-dimethyl-2-oxo-, (9.beta.,13.alpha.,14.beta.,20.alpha.)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Yang H, et al. Cancer Res. 2006 May 1;66(9):4758-65. 2. Yadav VR, et al. J Mol Med (Berl). 2010 Dec;88(12):1243-53. 3. Chen M, et al. Mol Cancer Res. 2009 Dec;7(12):1946-53. 4. Ge P, et al. Neurol Res. 2010 Feb;32(1):94-100.
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