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Carotuximab
CAS No. 1268714-50-6
Carotuximab( —— )
Catalog No. M36777 CAS No. 1268714-50-6
Carotuximab (DE-122) is a novel endocholine antibody with strong antiangiogenic and anti-inflammatory activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 375 | Get Quote |
|
| 5MG | 615 | Get Quote |
|
| 10MG | 938 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameCarotuximab
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NoteResearch use only, not for human use.
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Brief DescriptionCarotuximab (DE-122) is a novel endocholine antibody with strong antiangiogenic and anti-inflammatory activity.
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DescriptionCarotuximab (TRC105) is a IgG1 monoclonal antibody that blocks endoglin (CD105) and its downstream Smad signaling pathway. Carotuximab has immunomodulatory and antineoplastic actions.
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In VitroWestern Blot Analysis Cell Line:Human aortic endothelial cells (HAoECs) Concentration:300 μg/mL Incubation Time:Pretreatment 1 h, and then co-cultured for 12 h Result:Reduced the 7-Ketocholesterol-induced Eng protein levels and pSmad1/5 and pSmad2/3 signaling.
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In VivoAnimal Model:Female NSG (NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ; 7-8 weeks) injected with primary AML-0032 cells Dosage:2 mg/kg Administration:i.v; every 3 days; for 8 weeks Result:Along with Decitabine resulted in a more durable anti-leukemic effect in AML xenografts.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorTGF-beta/Smad | Immunology/Inflammation related
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Research Area——
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Indication——
Chemical Information
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CAS Number1268714-50-6
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Formula Weight
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Molecular Formula——
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Katarina Tripska , et al. Monoclonal anti-endoglin antibody TRC105 (carotuximab) prevents hypercholesterolemia and hyperglycemia-induced endothelial dysfunction in human aortic endothelial cells. Front Med (Lausanne). 2022 Sep 7;9:845918.?
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