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Cariporide
CAS No. 159138-80-4
Cariporide ( HOE642;HOE-642 )
Catalog No. M12272 CAS No. 159138-80-4
Cariporide (HOE642)is a potent, selective sodium-hydrogen exchange subtype 1 (NHE1) inhibitor with IC50 of 50 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 35 | In Stock |
|
| 10MG | 50 | In Stock |
|
| 25MG | 102 | In Stock |
|
| 50MG | 200 | In Stock |
|
| 100MG | 311 | In Stock |
|
| 500MG | 737 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCariporide
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NoteResearch use only, not for human use.
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Brief DescriptionCariporide (HOE642)is a potent, selective sodium-hydrogen exchange subtype 1 (NHE1) inhibitor with IC50 of 50 nM.
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DescriptionCariporide (HOE642)is a potent, selective sodium-hydrogen exchange subtype 1 (NHE1) inhibitor with IC50 of 50 nM, little to no activity against NHE3 and NHE2 (IC50=3 and 10 uM); inhibits the amiloride sensitive sodium influx in rabbit erythrocytes, reduces the swelling of human platelets induced by intracellular acidification, and delays pH recovery in rat cardiomyocytes; reduces and prevents ventricular premature beats, ventricular tachycardia, and ventricular fibrillation after oral treatment in vivo, shows cardioprotective and antiarrhythmic effects in ischaemic and reperfused hearts.Heart Arrhythmia Phase 2 Discontinued
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SynonymsHOE642;HOE-642
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PathwayMembrane Transporter/Ion Channel
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TargetSodium Channel
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RecptorNHE2
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Research AreaCardiovascular Disease
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IndicationHeart Arrhythmia
Chemical Information
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CAS Number159138-80-4
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Formula Weight283.35
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Molecular FormulaC12H17N3O3S
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Purity>98% (HPLC)
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SolubilityDMSO: 79 mg/mL (278.8 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESO=C(/N=C(N)\N)C1=CC=C(C(C)C)C(S(=O)(C)=O)=C1
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Chemical NameN-(Aminoiminomethyl)-4-(1-methylethyl)-3-(methylsulfonyl)benzamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Scholz W, et al. Cardiovasc Res. 1995 Feb;29(2):260-8.
2. Russ U, et al. Pflugers Arch. 1996 Nov-Dec;433(1-2):26-34.
3. Xue YX, et al. Eur J Pharmacol. 1996 Dec 19;317(2-3):309-16.
4. Aye NN, et al. Eur J Pharmacol. 1997 Nov 27;339(2-3):121-7.
2. Russ U, et al. Pflugers Arch. 1996 Nov-Dec;433(1-2):26-34.
3. Xue YX, et al. Eur J Pharmacol. 1996 Dec 19;317(2-3):309-16.
4. Aye NN, et al. Eur J Pharmacol. 1997 Nov 27;339(2-3):121-7.
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