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Caracemide

CAS No. 81424-67-1

Caracemide( NSC-253272 )

Catalog No. M26639 CAS No. 81424-67-1

Caracemide inhibits the enzyme ribonucleotide reductase of Escherichia coli. Caracemide can be used in anticancer studies.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Caracemide
  • Note
    Research use only, not for human use.
  • Brief Description
    Caracemide inhibits the enzyme ribonucleotide reductase of Escherichia coli. Caracemide can be used in anticancer studies.
  • Description
    Caracemide inhibits the enzyme ribonucleotide reductase of Escherichia coli. Caracemide can be used in anticancer studies.(In Vitro):Caracemide produces severe central nervous system (CNS) toxicity because of the toxic metabolite, methylisocyanate (MIC). Caracemide inactivates R1 by covalent modification at the substrate-binding site.(In Vivo):After administration of Caracemide (6.6 mg/kg;i.p.), the mercapturic acid derivative AMCC was identified in rats urine.
  • In Vitro
    Caracemide inactivates R1 by covalent modification at the substrate-binding site and has a toxic metabolite, methylisocyanate (MIC), in vivo.
  • In Vivo
    The mercapturic acid derivative AMCC was identified in urine rats following administration to rats of a single i.p. dose (6.6 mg/kg) of caracemide (NSC-253272). .
  • Synonyms
    NSC-253272
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Anti-infection| Bacterial
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    81424-67-1
  • Formula Weight
    189.171
  • Molecular Formula
    C6H11N3O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (528.63 mM)
  • SMILES
    CNC(=O)ON(C(C)=O)C(=O)NC
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Basanti LalHiran, et al. Oxidation of 3,4,5-trimethoxybenzaldehyde by pyridinium fluorochromate in N,N-dimethyl formamide medium: A kinetic and mechanistic study. Arabian Journal of Chemistry. Volume 9, Supplement 1, September 2016, Pages S440-S445
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