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Candoxatril

CAS No. 123122-55-4

Candoxatril( UK 79300 )

Catalog No. M10912 CAS No. 123122-55-4

The orally active prodrug of candoxatrilat (UK-73967), potent neutral endopeptidase EC 3.4.24.11 (atriopeptidase) inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Candoxatril
  • Note
    Research use only, not for human use.
  • Brief Description
    The orally active prodrug of candoxatrilat (UK-73967), potent neutral endopeptidase EC 3.4.24.11 (atriopeptidase) inhibitor.
  • Description
    The orally active prodrug of candoxatrilat (UK-73967), potent neutral endopeptidase EC 3.4.24.11 (atriopeptidase) inhibitor.Heart Failure Discontinued.
  • In Vitro
    ——
  • In Vivo
    While the NEP inhibitors have no significant effect on body weight, food and water intake, mean blood pressure or creatinine levels, they do increase cGMP levels in the urine and affected hematopoiesis in an anti-inflammatory way. Moreover, a-SMA deposition in the kidney cortex is inversely correlated with cGMP elevation suggesting a NEP dependent antifibroti effect. High quality mRNA profiles are obtained with at least 8 independent samples per treatment group. The data confirms the cGMP dependent anti-fibrotic action of Sol-1 and further supports the potential therapeutic actions of this neutral endopeptidase inhibitor.
  • Synonyms
    UK 79300
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Neprilysin
  • Recptor
    Neprilysin
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    123122-55-4
  • Formula Weight
    515.638
  • Molecular Formula
    C29H41NO7
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    COCCOCC(CC1(CCCC1)C(=O)NC2CCC(CC2)C(=O)O)C(=O)OC3=CC4=C(CCC4)C=C3
  • Chemical Name
    4-{[(1-{3-(2,3-dihydro-1H-inden-5-yloxy)-2-[(2-methoxyethoxy)methyl]-3-oxopropyl}cyclopentyl)carbonyl]amino}cyclohexanecarboxylic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Danilewicz JC, et al. Biochem Biophys Res Commun. 1989 Oct 16;164(1):58-65. 2. Shepperson NB, et al. Br J Pharmacol. 1989 Dec;98 Suppl:822P. 3. Jardine AG, et al. Am J Hypertens. 1990 Sep;3(9):661-7. 4. Northridge DB, et al. Lancet. 1989 Sep 9;2(8663):591-3.
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