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Camlipixant

CAS No. 1621164-74-6

Camlipixant( —— )

Catalog No. M36052 CAS No. 1621164-74-6

Camlipixant (BLU-5937) is an orally active purine P2X3 receptor antagonist that is potent, selective and competitive.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 227 Get Quote
10MG 370 Get Quote
25MG 679 Get Quote
50MG 1058 Get Quote
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Biological Information

  • Product Name
    Camlipixant
  • Note
    Research use only, not for human use.
  • Brief Description
    Camlipixant (BLU-5937) is an orally active purine P2X3 receptor antagonist that is potent, selective and competitive.
  • Description
    Camlipixant (BLU-5937) a potent, selective, non-competitive and orally active P2X3 homotrimeric receptor antagonist with an IC50 of 25 nM against hP2X3 homotrimeric. Camlipixant shows potent anti-tussive effect and no taste alteration. Camlipixant can be used for the research of unexplained, refractory chronic cough.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Male Dunkin Hartley guinea pigsDosage:0.3, 3, 30 mg/kg Administration:PO, approximately 2 h prior to tussive agent exposure Result:Significantly reduced the histamine-induced enhancement in the number of citric acid-induced coughs. Reduced significantly and dose-dependently the ATP-induced enhancement of citric acid-induced coughs.
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    P2X Receptor
  • Recptor
    P2X Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1621164-74-6
  • Formula Weight
    458.46
  • Molecular Formula
    C23H24F2N4O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (218.12 mM; Ultrasonic ) DMSO : 100 mg/mL (218.12 mM; ultrasonic and adjust pH to 3 with 1M HCl )
  • SMILES
    C(C1=C(N=C2N1C=CC(C)=C2)C3=C(F)C=C(C(NC)=O)C=C3F)[C@H]4CN(C(OC)=O)CCO4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Garceau D, Chauret N. BLU-5937: A selective P2X3 antagonist with potent anti-tussive effect and no taste alteration. Pulm Pharmacol Ther. 2019 Jun;56:56-62.?
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