CYP17-IN-1 ( —— )

Catalog No. M26134 CAS No. 2093317-51-0

CYP17-IN-1 is an effective oral CYP17 inhibitor that can inhibit CYP17 in rats and humans with IC50 of 15.8 and 20.1 nM.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

CYP17-IN-1
Note

Research use only, not for human use.
Brief Description

CYP17-IN-1 is an effective oral CYP17 inhibitor that can inhibit CYP17 in rats and humans with IC50 of 15.8 and 20.1 nM.
Description

CYP17-IN-1 is an effective oral CYP17 inhibitor that can inhibit CYP17 in rats and humans with IC50 of 15.8 and 20.1 nM.(In Vitro):The IC50 value of CYP17-IN-1 for CYP3A4 is 8.5 μM.(In Vivo):CYP17-IN-1 dose-dependently reduced plasma testosterone levels in Sprague-Dawley rats.
Synonyms

——
Pathway

Metabolic Enzyme/Protease
Target

P450
Recptor

carbonic anhydrase
Research Area

——
Indication

——

Chemical Information

CAS Number

2093317-51-0
Formula Weight

312.4
Molecular Formula

C18H17FN2S
Purity

>98% (HPLC)
Solubility

——
SMILES

Cc1ccncc1CN1CCc2c(C1)sc1ccc(F)cc21
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Prete SD, et, al. Escherichia coli γ-carbonic anhydrase: characterisation and effects of simple aromatic/heterocyclic sulphonamide inhibitors. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1545-1554.

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