SW063058 ( SW-063058 )

Catalog No. M14896 CAS No. 533876-30-1

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

SW063058
Note

Research use only, not for human use.
Brief Description

SW063058 is a small molecule that selectively disrupt Beclin 1/Bcl-2 binding as compared to Bax/Bcl-2 and Bim/Bcl-2 binding and induces autophagic flux at concentrations with minimal cytotoxicity.
Description

SW063058 is a small molecule that selectively disrupt Beclin 1/Bcl-2 binding as compared to Bax/Bcl-2 and Bim/Bcl-2 binding and induces autophagic flux at concentrations with minimal cytotoxicity.
Synonyms

SW-063058
Pathway

Angiogenesis
Target

Bcl-2
Recptor

Bcl-2
Research Area

——
Indication

——

CAS Number

533876-30-1
Formula Weight

565.18
Molecular Formula

C22H15BrFIN2O2
Purity

>98% (HPLC)
Solubility

——
SMILES

C1C(=O)NC2=C(C=C(C=C2)Br)C(N1C(=O)C3=CC=CC=C3I)C4=CC=C(C=C4)F
Chemical Name

7-bromo-5-(4-fluorophenyl)-4-(2-iodobenzoyl)-1,3,4,5-tetrahydro-2H-benzo[e][1,4]diazepin-2-one

1. Chiang WC, et al. ACS Chem Biol. 2018 Jun 21. doi: 10.1021/acschembio.8b00421.

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