CYC065
CAS No. 1070790-89-4
CYC065 ( CYC-065;CYC 065 )
Catalog No. M10291 CAS No. 1070790-89-4
CYC065 is a derivative of seliciclib and second generation CDK inhibitor that is mainly active on CDK2/5/9.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 155 | Get Quote |
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10MG | 282 | Get Quote |
|
25MG | 480 | Get Quote |
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50MG | 691 | Get Quote |
|
100MG | 972 | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
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Biological Information
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Product NameCYC065
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NoteResearch use only, not for human use.
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Brief DescriptionCYC065 is a derivative of seliciclib and second generation CDK inhibitor that is mainly active on CDK2/5/9.
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DescriptionCYC065 is a derivative of seliciclib and second generation CDK inhibitor that is mainly active on CDK2/5/9; demonstrates cytotoxicity both in MM cell lines sensitive as well as resistant to conventional chemotherapy with IC50 of 0.06-2 uM; blocks cells in the G1 phase and inhibits cell growth specifically in CCNE1-overexpressing USCs; significantly reduces tumour growth in xenografts derived from CCNE1-amplified USCs, shows synergistic effect in vitro and in vivo combined with Taselisib .Brain Cancer Phase 1 Clinical
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SynonymsCYC-065;CYC 065
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PathwayAngiogenesis
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TargetCDK
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RecptorCDK
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Research AreaCancer
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IndicationBrain Cancer
Chemical Information
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CAS Number1070790-89-4
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Formula Weight397.53
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Molecular FormulaC21H31N7O
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 100 mg/mL251.56 mM
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SMILESCCC(C(C)O)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CN=C(C=C3C)C
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Chemical Name(2R,3S)-3-[[6-[(4,6-dimethylpyridin-3-yl)methylamino]-9-propan-2-ylpurin-2-yl]amino]pentan-2-ol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Cocco E, et al. Br J Cancer. 2016 Jul 26;115(3):303-11.
2. Kawakami M, et al. J Natl Cancer Inst. 2017 Jun 1;109(6).
3. Thomas AL, et al. Cell Cycle. 2017 Aug 3;16(15):1453-1464.
4. Rao SS, et al. Oncotarget. 2017 Aug 10;8(48):83925-83939.
2. Kawakami M, et al. J Natl Cancer Inst. 2017 Jun 1;109(6).
3. Thomas AL, et al. Cell Cycle. 2017 Aug 3;16(15):1453-1464.
4. Rao SS, et al. Oncotarget. 2017 Aug 10;8(48):83925-83939.
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