CW069 ( CW069; CW-069; CW 069 )

Catalog No. M18087 CAS No. 1594094-64-0

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Group Booking Get Quotation Bulk Inquiry Add to Cart

Product Name

CW069
Note

Research use only, not for human use.
Brief Description

CW069(IC50=75 μM), an allosteric selective inhibitor of microtubule motor protein HSET, exhibits remarkable specificity over KSP.
Description

CW069 is an allosteric inhibitor of HSET. CW069 showed marked activity against HSET in vitro. The inhibitor induced multipolar mitoses only in cells containing supernumerary centrosomes. CW069 therefore constitutes a valuable tool for probing HSET function and, by reducing the growth of cells containing supernumerary centrosomes, paves the way for new cancer therapeutics.
Synonyms

CW069; CW-069; CW 069
Pathway

Others
Target

Other Targets
Recptor

HSET
Research Area

Cancer
Indication

——

CAS Number

1594094-64-0
Formula Weight

500.33
Molecular Formula

C23H21IN2O3
Purity

98%
Solubility

DMSO : ≥ 52 mg/mL; 103.93 mM
SMILES

O=C(O)c1cc(I)ccc1NC(=O)[C@@H](NCc1ccccc1)Cc1ccccc1
Chemical Name

5-Iodo-2-[[(2S)-1-oxo-3-phenyl-2-[(phenylmethyl)amino]propyl]amino]-benzoic acid

1. Watts CA, et al. Chem Biol. 2013, 20(11), 1399-1410.

Calculator

molnova catalog