CU-3

Research use only, not for human use.

CU-3 (DGKα inhibitor CU-3) is a novel potent, selective diacylglycerol kinase α (DGKα) inhibitor with IC50 of 0.6 uM.

CU-3 (DGKα inhibitor CU-3) is a novel potent, selective diacylglycerol kinase α (DGKα) inhibitor with IC50 of 0.6 uM, targets the catalytic region, but not the regulatory region; CU-3 competitively reduces the affinity of DGKα for ATP, but not diacylglycerol or phosphatidylserine, displays selectivity over other nine isozymes (IC50>7 uM); induces apoptosis in HepG2 hepatocellular carcinoma and HeLa cervical cancer cells while simultaneously enhancing the interleukin-2 production of Jurkat T cells.

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DGKα inhibitor CU-3

Others

DGK

DGK

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1815598-71-0

392.462

C16H12N2O4S3

>98% (HPLC)

In Vitro:?DMSO : 20 mg/mL (50.96 mM)

O=S(C1=CC=CC=C1)(NN(C/2=O)C(SC2=C/C=C/C3=CC=CO3)=S)=O

5-[(2E)-3-(2-furyl)prop-2-enylidene]-3-[(phenylsulfonyl)amino]2-thioxo-1,3-thiazolidin-4-one

(-20℃)

With Ice Pack

≥ 2 years