Cart
sales@molnova.com
CSN5i-3
CAS No. ——
CSN5i-3( CSN5 inhibitor 3 )
Catalog No. M17001 CAS No. ——
CSN5i-3 (CSN5 inhibitor 3)?is a potent, selective and orally available inhibitor of CSN5 with IC50 of 5.8 nM, the proteolytic subunit of COP9 signalosome (CSN).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameCSN5i-3
-
NoteResearch use only, not for human use.
-
Brief DescriptionCSN5i-3 (CSN5 inhibitor 3)?is a potent, selective and orally available inhibitor of CSN5 with IC50 of 5.8 nM, the proteolytic subunit of COP9 signalosome (CSN).
-
DescriptionCSN5i-3 (CSN5 inhibitor 3)?is a potent, selective and orally available inhibitor of CSN5 with IC50 of 5.8 nM, the proteolytic subunit of COP9 signalosome (CSN); displays >1,000-fold selectivity over JAMM domain proteases (Rpn11 and AMSHLP) and other metalloproteinases; inhibits CSN-catalysed Cul1 deneddylation with IC50 of 5.8 nM, traps the cullin-RING E3 ubiquitin ligases (CRLs) in the neddylated state, and results in the inactivation of a subset of CRLs and the stabilization of their substrates; exhibits a differentiating effect on the viability of cancer cells, inhibits growth of a human xenograft in vivo.
-
In Vitro——
-
In Vivo——
-
SynonymsCSN5 inhibitor 3
-
PathwayProteasome/Ubiquitin
-
TargetProteasome
-
RecptorProteasome
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number——
-
Formula Weight505.57
-
Molecular FormulaC28H29F2N5O2
-
Purity>98% (HPLC)
-
Solubility——
-
SMILES——
-
Chemical Name3-(difluoromethyl)-N-(6-((5S,6S)-6-hydroxy-6,7,8,9-tetrahydro-5H-imidazo[1,5-a]azepin-5-yl)-[1,1'-biphenyl]-3-yl)-1-isopropyl-1H-pyrazole-5-carboxamide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Schlierf A, et al. Nat Commun. 2016 Oct 24;7:13166.
molnova catalog
related products
-
PD-151746
A potent, selective, cell-permeable Calpain inhibitor with Ki of 0.26 uM for m-calpain.
-
Delanzomib
A potent, orally active proteasome inhibitor with IC50 of 3.8 nM against chymotrypsin-like proteasome activity.
-
VR-23
A potent inhibitor of trypsin-like proteasome (IC50=1 nM), chymotrypsin-like proteasome (IC50=50-100 nM) and caspase-like proteasome (IC50=3 uM).
