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Home - Products - GPCR/G Protein - Imidazoline Receptor - CR4056

CR4056

CAS No. 1004997-71-0

CR4056( CR 4056 | CR-4056 )

Catalog No. M10038 CAS No. 1004997-71-0

CR4056 (CR 4056, CR-4056) is a novel, orally active imidazoline-2 receptor (I2R) ligand with binding IC50 of 596 nM, also selectively inhibits the enzymatic activity of MAO-A with IC50 of 202.7 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    CR4056
  • Note
    Research use only, not for human use.
  • Brief Description
    CR4056 (CR 4056, CR-4056) is a novel, orally active imidazoline-2 receptor (I2R) ligand with binding IC50 of 596 nM, also selectively inhibits the enzymatic activity of MAO-A with IC50 of 202.7 nM.
  • Description
    CR4056 (CR 4056, CR-4056) is a novel, orally active imidazoline-2 receptor (I2R) ligand with binding IC50 of 596 nM, also selectively inhibits the enzymatic activity of MAO-A with IC50 of 202.7 nM; increases norepinephrine (NE) tissue levels both in the rat cerebral cortex and lumbar spinal cord, shows ED50 of 5.8 mg/kg in CFA rat model of inflammatory pain; shows high effectivity against bortezomib-induced painful neuropathy in rats.Pain Phase 2 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    CR 4056 | CR-4056
  • Pathway
    GPCR/G Protein
  • Target
    Imidazoline Receptor
  • Recptor
    Imidazoline Receptor
  • Research Area
    Neurological Disease
  • Indication
    Pain

Chemical Information

  • CAS Number
    1004997-71-0
  • Formula Weight
    272.311
  • Molecular Formula
    C17H12N4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C1(C2=CC=CC=C2)=NC=C3C=C(N4C=CN=C4)C=CC3=N1
  • Chemical Name
    6-(1H-imidazol-1-yl)-2-phenylquinazoline

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ferrari F, et al. J Pain Res. 2011;4:111-25. 2. Thorn DA, et al. Br J Pharmacol. 2012 Jul;166(6):1936-45. 3. Meregalli C, et al. J Pain Res. 2012;5:151-67. 4. Lanza M, et al. Br J Pharmacol. 2014 Aug;171(15):3693-701.
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