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CPYPP

CAS No. 310460-39-0

CPYPP ( —— )

Catalog No. M22074 CAS No. 310460-39-0

CPYPP is an inhibitor of DOCK2-Rac1 interaction. CPYPP binds to DOCK2 DHR-2 domain and inhibits the guanine nucleotide exchange factor (GEF) activity of DOCK2DHR-2 for Rac1 in a dose-dependent manner(IC50 : 22.8 μM).

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    CPYPP
  • Note
    Research use only, not for human use.
  • Brief Description
    CPYPP is an inhibitor of DOCK2-Rac1 interaction. CPYPP binds to DOCK2 DHR-2 domain and inhibits the guanine nucleotide exchange factor (GEF) activity of DOCK2DHR-2 for Rac1 in a dose-dependent manner(IC50 : 22.8 μM).
  • Description
    CPYPP is an inhibitor of DOCK2-Rac1 interaction. CPYPP binds to DOCK2 DHR-2 domain and inhibits the guanine nucleotide exchange factor (GEF) activity of DOCK2DHR-2 for Rac1 in a dose-dependent manner(IC50 : 22.8 μM). CPYPP also inhibits DOCK180, DOCK5 and less DOCK9CPYPP as a small-molecule inhibitor of DOCK2.?CPYPP bound to DOCK2 DHR-2 domain in a reversible manner and inhibited its catalytic activity in vitro.?When lymphocytes were treated with CPYPP, both chemokine receptor- and antigen receptor-mediated Rac activation were blocked, resulting in marked reduction of chemotactic response and T cell activation.?These results provide a rational of and a chemical scaffold for development of the DOCK2-targeting immunosuppressant.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    DOCK2-Rac1;DOCK180;DOCK5;DOCK9
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    310460-39-0
  • Formula Weight
    324.76
  • Molecular Formula
    C18H13ClN2O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 23 mg/mL (70.82 mM; Need ultrasonic)
  • SMILES
    ClC1=CC=CC=C1C=CC=C1C(=O)NN(C1=O)C1=CC=CC=C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Nishikimi A, et al. Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2. Chem Biol. 2012 Apr 20;19(4):488-97.
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