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CPYPP
CAS No. 310460-39-0
CPYPP( —— )
Catalog No. M22074 CAS No. 310460-39-0
CPYPP is an inhibitor of DOCK2-Rac1 interaction. CPYPP binds to DOCK2 DHR-2 domain and inhibits the guanine nucleotide exchange factor (GEF) activity of DOCK2DHR-2 for Rac1 in a dose-dependent manner(IC50 : 22.8 μM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 72 | Get Quote |
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| 10MG | 110 | Get Quote |
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| 25MG | 222 | Get Quote |
|
| 50MG | 356 | Get Quote |
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| 100MG | 533 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameCPYPP
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NoteResearch use only, not for human use.
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Brief DescriptionCPYPP is an inhibitor of DOCK2-Rac1 interaction. CPYPP binds to DOCK2 DHR-2 domain and inhibits the guanine nucleotide exchange factor (GEF) activity of DOCK2DHR-2 for Rac1 in a dose-dependent manner(IC50 : 22.8 μM).
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DescriptionCPYPP is an inhibitor of DOCK2-Rac1 interaction. CPYPP binds to DOCK2 DHR-2 domain and inhibits the guanine nucleotide exchange factor (GEF) activity of DOCK2DHR-2 for Rac1 in a dose-dependent manner(IC50 : 22.8 μM). CPYPP also inhibits DOCK180, DOCK5 and less DOCK9CPYPP as a small-molecule inhibitor of DOCK2.?CPYPP bound to DOCK2 DHR-2 domain in a reversible manner and inhibited its catalytic activity in vitro.?When lymphocytes were treated with CPYPP, both chemokine receptor- and antigen receptor-mediated Rac activation were blocked, resulting in marked reduction of chemotactic response and T cell activation.?These results provide a rational of and a chemical scaffold for development of the DOCK2-targeting immunosuppressant.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorDOCK2-Rac1|DOCK180|DOCK5|DOCK9
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Research Area——
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Indication——
Chemical Information
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CAS Number310460-39-0
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Formula Weight324.76
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Molecular FormulaC18H13ClN2O2
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Purity>98% (HPLC)
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SolubilityDMSO : 23 mg/mL (70.82 mM; Need ultrasonic)
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SMILESClC1=CC=CC=C1C=CC=C1C(=O)NN(C1=O)C1=CC=CC=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Nishikimi A, et al. Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2. Chem Biol. 2012 Apr 20;19(4):488-97.
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