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CPTH6
CAS No. 1099614-81-9
CPTH6( —— )
Catalog No. M10380 CAS No. 1099614-81-9
CPTH6 is a thiazole derivative that can reduce histone acetylation and histone acetyltransferase (HAT) activity in human leukemia cells, CPTH6 is a specific Gcn5/pCAF inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameCPTH6
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NoteResearch use only, not for human use.
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Brief DescriptionCPTH6 is a thiazole derivative that can reduce histone acetylation and histone acetyltransferase (HAT) activity in human leukemia cells, CPTH6 is a specific Gcn5/pCAF inhibitor.
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DescriptionCPTH6 is a thiazole derivative that can reduce histone acetylation and histone acetyltransferase (HAT) activity in human leukemia cells, CPTH6 is a specific Gcn5/pCAF inhibitor; CPTH6 exerts a significant inhibitory effect on HAT activity of both pCAF and Gcn5, whereas it does not affect p300 and CBP HAT activity; decrease acetylation of histone H3 specifically at lysine 18 in a dose-dependent fashion, does not affect H3 histone methylation at lysines 9 and 4; induces cell-cycle perturbation and apoptosis in AML cells, induces differentiation in AML and neuroblastoma cells; impairs autophagy and reduces autophagosome turnover through an impairment of their degradation pathway.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayChromatin/Epigenetic
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TargetHAT
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RecptorHAT
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Research Area——
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Indication——
Chemical Information
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CAS Number1099614-81-9
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Formula Weight305.824
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Molecular FormulaC15H16ClN3S
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Purity>98% (HPLC)
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Solubility——
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SMILESCC1CCC(=NNC2=NC(=CS2)C3=CC=C(C=C3)Cl)C1
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Chemical NameCyclopentanone, 3-methyl-, 2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Trisciuoglio D, et al. Clin Cancer Res. 2012 Jan 15;18(2):475-86.
2. Ragazzoni Y, et al. Cell Death Dis. 2013 Mar 7;4:e524.
3. Di Martile M, et al. Oncotarget. 2016 Mar 8;7(10):11332-48.
4. Chimenti F, et al. J Med Chem. 2009 Jan 22;52(2):530-6.
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