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CPSI-1306

CAS No. 1309793-47-2

CPSI-1306 ( cpsi-1306; 2-(3-(2,4-Difluorophenyl)-4,5-dihydroisoxazol-5-yl)-1-morpholinoethan-1-one )

Catalog No. M26869 CAS No. 1309793-47-2

(±)-CPSI-1306 is a macrophage migration inhibitory factor (MIF) antagonist and can be used in studies about non-insulin-dependent diabetes mellitus (NIDDM) and the prevention of the deleterious cutaneous effects of acute and chronic UVB exposure.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    CPSI-1306
  • Note
    Research use only, not for human use.
  • Brief Description
    (±)-CPSI-1306 is a macrophage migration inhibitory factor (MIF) antagonist and can be used in studies about non-insulin-dependent diabetes mellitus (NIDDM) and the prevention of the deleterious cutaneous effects of acute and chronic UVB exposure.
  • Description
    (±)-CPSI-1306 is a macrophage migration inhibitory factor (MIF) antagonist and can be used in studies about non-insulin-dependent diabetes mellitus (NIDDM) and the prevention of the deleterious cutaneous effects of acute and chronic UVB exposure.(In Vivo):In mice, (±)-CPSI-1306 decreases their blood glucose levels and can be effective in treating non-insulin-dependent diabetes mellitus (NIDDM) as characterized by high serum levels of glucose and inflammatory cytokine. (±)-CPSI-1306-induced keratinocyte apoptosis is appreciated 30 minutes after a single UVB exposure. (±)-CPSI-1306-treated mice show a significant increase in expression of cleaved caspase-3 at 6, 24, and 48 hours following UVB exposure. (±)-CPSI-1306 reduces acute UVB-induced keratinocyte DNA damage and UVB-induced acute inflammation.
  • Synonyms
    cpsi-1306; 2-(3-(2,4-Difluorophenyl)-4,5-dihydroisoxazol-5-yl)-1-morpholinoethan-1-one
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    AddAB helicase-nuclease; RecBCD helicase-nuclease
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1309793-47-2
  • Formula Weight
    310.3
  • Molecular Formula
    C15H16F2N2O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Fc1ccc(C2=NOC(CC(=O)N3CCOCC3)C2)c(F)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Bannister TD, et al. ML328: A Novel Dual Inhibitor of Bacterial AddAB and RecBCD Helicase-nuclease DNA Repair Enzymes. 2012 Dec 17 [updated 2013 Apr 5]. In: Probe Reports from the NIH Molecular Libraries Program [Internet].
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