CPI644 ( CPI 644;CPI-644 )

Catalog No. M12986 CAS No. 1904647-34-2

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Datasheet

HNMR

HPLC

MSDS

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Product Name

CPI644
Note

Research use only, not for human use.
Brief Description

CPI644is a potent, selective, cell-active CBP/EP300 bromodomain inhibitor.
Description

CPI644is a potent, selective, cell-active CBP/EP300 bromodomain inhibitor with IC50 of 0.18 uM for CBP; displays little to no (>400-fold selectivity) activity for BRD9, BRD4, BRPF1, TRIM24, BRG1 and BACF (IC50>10 uM); inhibits CBP bromodomain binding in a dose-dependent manner with cellular EC50 of 0.53 uM, reduces FOXP3 expression both at protein and transcript levels with no appreciable effect on cell viability.
Synonyms

CPI 644;CPI-644
Pathway

Chromatin/Epigenetic
Target

Bromodomain
Recptor

Bromodomain
Research Area

——
Indication

——

CAS Number

1904647-34-2
Formula Weight

357.43
Molecular Formula

C18H19N3O3S
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C1NC2=CC=CC(C3=NC(C)=CN3C)=C2N[C@H](C)C1
Chemical Name

(R,E)-2-(2-(4-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-6-yl)vinyl)benzenesulfonamide

1. Ghosh S, et al. J Biol Chem. 2016 Jun 17;291(25):13014-27.

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