CP-9( Hsp90α inhibitor CP-9 )

Catalog No. M14720 CAS No. 505056-50-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

CP-9
Note

Research use only, not for human use.
Brief Description

A potent Hsp90α/p23 interaction inhibitor with IC50 of 3.2 uM; 5-fold less potent for Hsp90β/p23 interaction (IC50=15.3 uM).
Description

A potent Hsp90α/p23 interaction inhibitor with IC50 of 3.2 uM; 5-fold less potent for Hsp90β/p23 interaction (IC50=15.3 uM); leads to various levels of degradation of pAkt/total Akt and Raf-1 in cancer cell lines, but has no effect on the expression of the Hsp90 client proteins in normal mouse embryonic fibroblasts (MEFs); inhibits cell proliferation, glucose metabolism, and mammalian thymidine kinase activities in multiple cancer cell lines.
In Vitro

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In Vivo

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Synonyms

Hsp90α inhibitor CP-9
Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

HSP
Recptor

HSP
Research Area

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Indication

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CAS Number

505056-50-8
Formula Weight

400.394
Molecular Formula

C15H11F3N4O2S2
Purity

>98% (HPLC)
Solubility

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SMILES

CC1=CC(=NO1)NC(=O)CSC2=NC(=CC(=N2)C(F)(F)F)C3=CC=CS3
Chemical Name

N-(5-methylisoxazol-3-yl)-2-[4-(thiophen-2-yl)-6-(trifluoromethyl)pyrimidin-2-ylthio]acetamide

1. Chan CT, et al. Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):E2476-85.

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