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CP-724714
CAS No. 383432-38-0
CP-724714 ( CP724714; CP 724714; CP-724714 )
Catalog No. M17499 CAS No. 383432-38-0
CP-724714 is an effective and selective HER2/ErbB2 inhibitor (IC50: 10 nM), >640-fold selectivity against EGFR, Abl, InsR, PDGFR, IRG-1R, Src, VEGFR2, c-Met etc.
Purity : 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 48 | In Stock |
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| 5MG | 78 | In Stock |
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| 10MG | 143 | In Stock |
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| 25MG | 258 | In Stock |
|
| 50MG | 429 | In Stock |
|
| 100MG | 626 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCP-724714
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NoteResearch use only, not for human use.
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Brief DescriptionCP-724714 is an effective and selective HER2/ErbB2 inhibitor (IC50: 10 nM), >640-fold selectivity against EGFR, Abl, InsR, PDGFR, IRG-1R, Src, VEGFR2, c-Met etc.
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DescriptionCP-724714 is An orally bioavailable quinazoline with potential antineoplastic activity. CP-724,714 selectively binds to the intracellular domain of HER2, reversibly inhibiting its tyrosine kinase activity and resulting in suppression of tumor cell growth. HER2, a member of the epidermal growth factor receptor (EGFR) family, is overexpressed in many adenocarcinomas, particularly breast cancers.
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SynonymsCP724714; CP 724714; CP-724714
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PathwayGPCR/G Protein
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TargetCannabinoid Receptor
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RecptorHER2/ErbB2
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number383432-38-0
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Formula Weight469.54
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Molecular FormulaC27H27N5O3
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Purity98%
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SolubilityDMSO : ≥ 50 mg/mL; 106.49 mM
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SMILESCc1ncc(cc1)Oc1c(cc(cc1)Nc1ncnc2c1cc(cc2)/C=C/CNC(=O)COC)C
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Chemical Name(E)-2-methoxy-N-(3-(4-(3-methyl-4-(6-methylpyridin-3-yloxy)phenylamino)quinazolin-6-yl)allyl)acetamide.
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Jani JP, et al. Discovery and pharmacologic characterization of CP-724,714, a selective ErbB2 tyrosine kinase inhibitor. Cancer Res, 2007, 67(20), 9887-9893.
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