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Home - Products - GPCR/G Protein - Cannabinoid Receptor - CP-724714

CP-724714

CAS No. 383432-38-0

CP-724714 ( CP724714; CP 724714; CP-724714 )

Catalog No. M17499 CAS No. 383432-38-0

CP-724714 is an effective and selective HER2/ErbB2 inhibitor (IC50: 10 nM), >640-fold selectivity against EGFR, Abl, InsR, PDGFR, IRG-1R, Src, VEGFR2, c-Met etc.

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    CP-724714
  • Note
    Research use only, not for human use.
  • Brief Description
    CP-724714 is an effective and selective HER2/ErbB2 inhibitor (IC50: 10 nM), >640-fold selectivity against EGFR, Abl, InsR, PDGFR, IRG-1R, Src, VEGFR2, c-Met etc.
  • Description
    CP-724714 is An orally bioavailable quinazoline with potential antineoplastic activity. CP-724,714 selectively binds to the intracellular domain of HER2, reversibly inhibiting its tyrosine kinase activity and resulting in suppression of tumor cell growth. HER2, a member of the epidermal growth factor receptor (EGFR) family, is overexpressed in many adenocarcinomas, particularly breast cancers.
  • Synonyms
    CP724714; CP 724714; CP-724714
  • Pathway
    GPCR/G Protein
  • Target
    Cannabinoid Receptor
  • Recptor
    HER2/ErbB2
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    383432-38-0
  • Formula Weight
    469.54
  • Molecular Formula
    C27H27N5O3
  • Purity
    98%
  • Solubility
    DMSO : ≥ 50 mg/mL; 106.49 mM
  • SMILES
    Cc1ncc(cc1)Oc1c(cc(cc1)Nc1ncnc2c1cc(cc2)/C=C/CNC(=O)COC)C
  • Chemical Name
    (E)-2-methoxy-N-(3-(4-(3-methyl-4-(6-methylpyridin-3-yloxy)phenylamino)quinazolin-6-yl)allyl)acetamide.

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Jani JP, et al. Discovery and pharmacologic characterization of CP-724,714, a selective ErbB2 tyrosine kinase inhibitor. Cancer Res, 2007, 67(20), 9887-9893.
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