AM9405 ( AM-9405;GAT379;GAT-379 )

Catalog No. M17035 CAS No.

COA

Datasheet

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Product Name

AM9405
Note

Research use only, not for human use.
Brief Description

AM9405 (AM-9405, GAT-379) is novel potent, peripherally active cannabinoid type 1 (CB1) and 5-HT3 receptor agonist.
Description

AM9405 (AM-9405, GAT-379) is novel potent, peripherally active cannabinoid type 1 (CB1) and 5-HT3 receptor agonist, inhibits the EFS-induced twitch contraction of the ileum and the colon with IC50 of 0.076 and 45.71 nM, respectively; significantly slows mouse intestinal motility in physiological conditions, reverses hypermotility and reduced pain in mouse models mimicking symptoms of functional GI disorders, such as stress-induced diarrhea and writhing test.
Synonyms

AM-9405;GAT379;GAT-379
Pathway

GPCR/G Protein
Target

Cannabinoid Receptor
Recptor

Cannabinoid Receptor
Research Area

——
Indication

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CAS Number

--
Formula Weight

461.44
Molecular Formula

C24H33BrN2O2
Purity

>98% (HPLC)
Solubility

——
SMILES

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Chemical Name

2-(2,6-dihydroxy-4-(2-methyloctan-2-yl)phenyl)-1,3-dimethyl-1H-benzo[d]imidazol-3-ium bromide

1. Salaga M, et al. Eur J Pharmacol. 2018 Aug 17;836:34-43.

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