CO-1686

Research use only, not for human use.

A potent, highly selective, irreversible inhibitor of mutant EGFR with Ki of 21.5 nM for EGFR L858R/T790M.

A potent, highly selective, irreversible inhibitor of mutant EGFR with Ki of 21.5 nM for EGFR L858R/T790M; shows 22-fold selective over WT EGFR; EGFR del19, T790M, L858R/T790M and L858R mutant kinases demonstrates the highest degree of inhibition at 0.1 uM; orally bioavailable.Lung Cancer Withdrawn

Rociletinib;AVL-301;CNX-419

Angiogenesis

EGFR

EGFR(L858R/T790M);EGFR(wt)

Cancer

Lung Cancer

1374640-70-6

555.55

C27H28F3N7O3

>98% (HPLC)

DMSO: ≥ 43 mg/mL

C=CC(NC1=CC=CC(NC2=NC(NC3=CC=C(N4CCN(C(C)=O)CC4)C=C3OC)=NC=C2C(F)(F)F)=C1)=O

2-Propenamide, N-[3-[[2-[[4-(4-acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-

(-20℃)

With Ice Pack

≥ 2 years