CO-1686
CAS No. 1374640-70-6
CO-1686 ( Rociletinib;AVL-301;CNX-419 )
Catalog No. M11548 CAS No. 1374640-70-6
A potent, highly selective, irreversible inhibitor of mutant EGFR with Ki of 21.5 nM for EGFR L858R/T790M.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 41 | Get Quote |
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10MG | 61 | Get Quote |
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25MG | 90 | Get Quote |
|
50MG | 113 | Get Quote |
|
100MG | 186 | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
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Biological Information
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Product NameCO-1686
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, highly selective, irreversible inhibitor of mutant EGFR with Ki of 21.5 nM for EGFR L858R/T790M.
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DescriptionA potent, highly selective, irreversible inhibitor of mutant EGFR with Ki of 21.5 nM for EGFR L858R/T790M; shows 22-fold selective over WT EGFR; EGFR del19, T790M, L858R/T790M and L858R mutant kinases demonstrates the highest degree of inhibition at 0.1 uM; orally bioavailable.Lung Cancer Withdrawn
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SynonymsRociletinib;AVL-301;CNX-419
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PathwayAngiogenesis
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TargetEGFR
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RecptorEGFR(L858R/T790M);EGFR(wt)
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Research AreaCancer
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IndicationLung Cancer
Chemical Information
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CAS Number1374640-70-6
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Formula Weight555.55
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Molecular FormulaC27H28F3N7O3
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 43 mg/mL
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SMILESC=CC(NC1=CC=CC(NC2=NC(NC3=CC=C(N4CCN(C(C)=O)CC4)C=C3OC)=NC=C2C(F)(F)F)=C1)=O
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Chemical Name2-Propenamide, N-[3-[[2-[[4-(4-acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Walter AO, et al. Cancer Discov. 2013 Dec;3(12):1404-15.
2. Tjin Tham Sjin R, et al. Mol Cancer Ther. 2014 Jun;13(6):1468-79.
3. Sequist LV, et al. N Engl J Med. 2015 Apr 30;372(18):1700-9.
2. Tjin Tham Sjin R, et al. Mol Cancer Ther. 2014 Jun;13(6):1468-79.
3. Sequist LV, et al. N Engl J Med. 2015 Apr 30;372(18):1700-9.
molnova catalog
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