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CO-1686

CAS No. 1374640-70-6

CO-1686 ( Rociletinib;AVL-301;CNX-419 )

Catalog No. M11548 CAS No. 1374640-70-6

A potent, highly selective, irreversible inhibitor of mutant EGFR with Ki of 21.5 nM for EGFR L858R/T790M.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    CO-1686
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, highly selective, irreversible inhibitor of mutant EGFR with Ki of 21.5 nM for EGFR L858R/T790M.
  • Description
    A potent, highly selective, irreversible inhibitor of mutant EGFR with Ki of 21.5 nM for EGFR L858R/T790M; shows 22-fold selective over WT EGFR; EGFR del19, T790M, L858R/T790M and L858R mutant kinases demonstrates the highest degree of inhibition at 0.1 uM; orally bioavailable.Lung Cancer Withdrawn
  • Synonyms
    Rociletinib;AVL-301;CNX-419
  • Pathway
    Angiogenesis
  • Target
    EGFR
  • Recptor
    EGFR(L858R/T790M);EGFR(wt)
  • Research Area
    Cancer
  • Indication
    Lung Cancer

Chemical Information

  • CAS Number
    1374640-70-6
  • Formula Weight
    555.55
  • Molecular Formula
    C27H28F3N7O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 43 mg/mL
  • SMILES
    C=CC(NC1=CC=CC(NC2=NC(NC3=CC=C(N4CCN(C(C)=O)CC4)C=C3OC)=NC=C2C(F)(F)F)=C1)=O
  • Chemical Name
    2-Propenamide, N-[3-[[2-[[4-(4-acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Walter AO, et al. Cancer Discov. 2013 Dec;3(12):1404-15.
2. Tjin Tham Sjin R, et al. Mol Cancer Ther. 2014 Jun;13(6):1468-79.
3. Sequist LV, et al. N Engl J Med. 2015 Apr 30;372(18):1700-9.
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