Pyrotinib ( SHR-1258;SHR1258 )

Catalog No. M11130 CAS No. 1269662-73-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Pyrotinib
Note

Research use only, not for human use.
Brief Description

Pyrotinib (SHR-1258)is a potent and selective EGFR/HER2 dual inhibitor with IC50 of 13/38 nM, respectively.
Description

Pyrotinib (SHR-1258)is a potent and selective EGFR/HER2 dual inhibitor with IC50 of 13/38 nM, respectively; displays high selectivity in a panel of different kinases such as KDR, c-Kit, PDGFRβ, c-Src and c-Met (c-Src with an IC50 of 790 nM, and others >3,000 nM); exhibits robust anti-tumor effects on HER2-overexpressing xenograft models and sufficiently safety windows in animals as well as favorable pharmacokinetic properties in human. Breast Cancer Phase 3 Clinical
Synonyms

SHR-1258;SHR1258
Pathway

Angiogenesis
Target

EGFR
Recptor

EGFR
Research Area

Cancer
Indication

Breast Cancer

CAS Number

1269662-73-8
Formula Weight

583.09
Molecular Formula

C32H31ClN6O3
Purity

>98% (HPLC)
Solubility

DMSO : 0.172 mg/mL 0.29 mM
SMILES

CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)OCC4=CC=CC=N4)Cl)C#N)NC(=O)C=CC5CCCN5C
Chemical Name

(R,E)-N-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-3-(1-methylpyrrolidin-2-yl)acrylamide

1. Li X, et al. Eur J Pharm Sci. 2017 Jan 21. pii: S0928-0987(17)30043-X.

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