CL27c ( —— )

Catalog No. M11569 CAS No. 1380227-11-1

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Datasheet

HNMR

HPLC

MSDS

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Product Name

CL27c
Note

Research use only, not for human use.
Brief Description

CL27c is a cell-permeable, inhaled lipophilic ester prodrug of CL27e, which is a potent, selective pan-class I PI3K inhibitor, CL27c is inactive in PI3K enzymatic assay.
Description

CL27c is a cell-permeable, inhaled lipophilic ester prodrug of CL27e, which is a potent, selective pan-class I PI3K inhibitor, CL27c is inactive in PI3K enzymatic assay, once inside the cytoplasm, CL27c is metabolized by unspecific esterases into CL27e; readily reduces Akt/PKB phosphorylation in chronic lymphocytic leukemia (CLL) cells stimulated with anti-IgM antibodies, as well as in murine neutrophils and bone marrow-derived macrophages (BMDM) stimulated with C5a; reduces insulin-evoked Akt phosphorylation in lungs, but no change in other tissues and no increase in blood glycaemia, in line with a local action; reduces inflammation and improves lung function in murine models of acute or glucocorticoid-resistant neutrophilic asthma.
Synonyms

——
Pathway

PI3K/Akt/mTOR signaling
Target

PI3K
Recptor

PI3K
Research Area

——
Indication

——

CAS Number

1380227-11-1
Formula Weight

445.48
Molecular Formula

C24H23N5O4
Purity

>98% (HPLC)
Solubility

——
SMILES

——
Chemical Name

methyl 3-((4-(2-morpholino-4-oxo-1,4-dihydroquinolin-8-yl)-1H-1,2,3-triazol-1-yl)methyl)benzoate

1. Campa CC, et al. Nat Commun. 2018 Dec 12;9(1):5232.
2. Pirali T, et al. ChemMedChem. 2017 Sep 21;12(18):1542-1554.

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