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CL27c
CAS No. 1380227-11-1
CL27c ( —— )
Catalog No. M11569 CAS No. 1380227-11-1
CL27c is a cell-permeable, inhaled lipophilic ester prodrug of CL27e, which is a potent, selective pan-class I PI3K inhibitor, CL27c is inactive in PI3K enzymatic assay.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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| 100MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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Biological Information
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Product NameCL27c
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NoteResearch use only, not for human use.
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Brief DescriptionCL27c is a cell-permeable, inhaled lipophilic ester prodrug of CL27e, which is a potent, selective pan-class I PI3K inhibitor, CL27c is inactive in PI3K enzymatic assay.
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DescriptionCL27c is a cell-permeable, inhaled lipophilic ester prodrug of CL27e, which is a potent, selective pan-class I PI3K inhibitor, CL27c is inactive in PI3K enzymatic assay, once inside the cytoplasm, CL27c is metabolized by unspecific esterases into CL27e; readily reduces Akt/PKB phosphorylation in chronic lymphocytic leukemia (CLL) cells stimulated with anti-IgM antibodies, as well as in murine neutrophils and bone marrow-derived macrophages (BMDM) stimulated with C5a; reduces insulin-evoked Akt phosphorylation in lungs, but no change in other tissues and no increase in blood glycaemia, in line with a local action; reduces inflammation and improves lung function in murine models of acute or glucocorticoid-resistant neutrophilic asthma.
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Synonyms——
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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RecptorPI3K
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Research Area——
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Indication——
Chemical Information
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CAS Number1380227-11-1
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Formula Weight445.48
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Molecular FormulaC24H23N5O4
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Namemethyl 3-((4-(2-morpholino-4-oxo-1,4-dihydroquinolin-8-yl)-1H-1,2,3-triazol-1-yl)methyl)benzoate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Campa CC, et al. Nat Commun. 2018 Dec 12;9(1):5232.
2. Pirali T, et al. ChemMedChem. 2017 Sep 21;12(18):1542-1554.
2. Pirali T, et al. ChemMedChem. 2017 Sep 21;12(18):1542-1554.
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