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Home - Products - Apoptosis - NF-κB - CL075

CL075

CAS No. 256922-53-9

CL075( —— )

Catalog No. M34210 CAS No. 256922-53-9

CL075 (3M002) is a selective TLR8 agonist with immunomodulatory activity, triggering the MyD88-dependent signaling pathway and activating NF-κB and IRF7 to elicit the production of inflammatory cytokines and type I interferon (IFN).

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    CL075
  • Note
    Research use only, not for human use.
  • Brief Description
    CL075 (3M002) is a selective TLR8 agonist with immunomodulatory activity, triggering the MyD88-dependent signaling pathway and activating NF-κB and IRF7 to elicit the production of inflammatory cytokines and type I interferon (IFN).
  • Description
    CL075 (3M002) is a selective TLR8 agonist with immunomodulating properties. CL075 triggers a MyD88-dependent signaling pathway to elicit production of inflammatory cytokines and type I interferons (IFNs) via activation of NF-κB and IRF7, respectively.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    NF-κB
  • Recptor
    NF-κB | MyD88 | TLR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    256922-53-9
  • Formula Weight
    243.33
  • Molecular Formula
    C13H13N3S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 22 mg/mL (90.41 mM; 超声加热助溶)
  • SMILES
    CCCc1nc2c(N)nc3ccccc3c2s1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lai CY, et, al. TLR7/8 agonists activate a mild immune response in rabbits through TLR8 but not TLR7. Vaccine. 2014 Sep 29;32(43):5593-9.?
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