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CI-976

CAS No. 114289-47-3

CI-976 ( PD 128042 )

Catalog No. M10507 CAS No. 114289-47-3

CI-976 (PD 128042) is a potent, selective, orally bioavailable inhibitor of ACAT-1 (Acetyl-CoA acetyltransferase 1) with IC50 of 73 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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2MG 55 Get Quote
5MG 78 Get Quote
10MG 116 Get Quote
25MG 251 Get Quote
50MG 467 Get Quote
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Biological Information

  • Product Name
    CI-976
  • Note
    Research use only, not for human use.
  • Brief Description
    CI-976 (PD 128042) is a potent, selective, orally bioavailable inhibitor of ACAT-1 (Acetyl-CoA acetyltransferase 1) with IC50 of 73 nM.
  • Description
    CI-976 (PD 128042) is a potent, selective, orally bioavailable inhibitor of ACAT-1 (Acetyl-CoA acetyltransferase 1) with IC50 of 73 nM; decreases plasma total cholesterol, very low density lipoprotein (VLDL) cholesterol, LDL cholesterol, apolipoprotein B, liver cholesteryl esters, and VLDL and LDL cholesteryl ester content in rabbits.Atherosclerosis Discontinued
  • Synonyms
    PD 128042
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Other Targets
  • Research Area
    Cardiovascular Disease
  • Indication
    Atherosclerosis

Chemical Information

  • CAS Number
    114289-47-3
  • Formula Weight
    393.57
  • Molecular Formula
    C23H39NO4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CCCCCCCCCCC(C)(C)C(=O)NC1=C(C=C(C=C1OC)OC)OC
  • Chemical Name
    2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)-dodecanamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Field FJ, et al. Lipids. 1991 Jan;26(1):1-8.
2. O'Brien PM, et al. J Med Chem. 1994 Jun 10;37(12):1810-22.
3. Krause BR, et al. J Lipid Res. 1993 Feb;34(2):279-94.
4. Baba T, et al. Mol Cell Biochem. 2013 Apr;376(1-2):151-61.
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