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CI-1044
CAS No. 197894-84-1
CI-1044 ( CI1044 )
Catalog No. M13094 CAS No. 197894-84-1
CI-1044 is a potent, selective and orally bioavailable PDE4 inhibitor with IC50 of 0.27 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 267 | Get Quote |
|
| 50MG | 1224 | Get Quote |
|
| 100MG | 1674 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameCI-1044
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NoteResearch use only, not for human use.
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Brief DescriptionCI-1044 is a potent, selective and orally bioavailable PDE4 inhibitor with IC50 of 0.27 uM.
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DescriptionCI-1044 is a potent, selective and orally bioavailable PDE4 inhibitor with IC50 of 0.27 uM, displays high selectivity for PDE4 versus PDE1/3/5, and no PDE4 subtype (4A-D) selectivities; exhibits efficient in vitro inhibition of TNFα release from hPBMC and hWB with IC50 of 0.34 and 0.84 uM, respectively; exhibits potent in vivo activity in antigen-induced eosinophil recruitment in rats (ED50=3.2 mg/kg, p.o.).Asthma Phase 1 Clinical
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SynonymsCI1044
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PathwayAngiogenesis
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TargetPDE
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RecptorPDE
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Research AreaInflammation/Immunology
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IndicationAsthma
Chemical Information
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CAS Number197894-84-1
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Formula Weight397.44
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Molecular FormulaC23H19N5O2
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Purity>98% (HPLC)
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SolubilityDMSO : 125 mg/mL 314.52 mM
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SMILESNc1cc2CCN3C(=O)[C@H](NC(=O)c4cccnc4)N=C(c5ccccc5)c(c1)c23
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Chemical Name(R)-N-(9-amino-4-oxo-1-phenyl-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-3-yl)nicotinamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Burnouf C, et al. J Med Chem. 2000 Dec 14;43(25):4850-67.
2. Ouagued M, et al. Pulm Pharmacol Ther. 2005;18(1):49-54.
3. Hanton G, et al. Toxicol Lett. 2008 Jun 10;179(1):15-22.
2. Ouagued M, et al. Pulm Pharmacol Ther. 2005;18(1):49-54.
3. Hanton G, et al. Toxicol Lett. 2008 Jun 10;179(1):15-22.
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