AZD1283 ( AZD-1283; AZD1283; AZD 1283 )

Catalog No. M17661 CAS No. 919351-41-0

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Group Booking Get Quotation Bulk Inquiry Add to Cart

Product Name

AZD1283
Note

Research use only, not for human use.
Brief Description

AZD1283 is an effective P2Y12 receptor antagonist (EC50: 3.0 ug/kg/min, binding IC50: 11 nM).
Description

AZD1283 is a potent antagonist of the P2Y12 receptor. In a modified Folts model in dog, both AZD1283 dose-dependently induced increases in blood flow and inhibition of ADP-induced platelet aggregation with antithrombotic ED50 values of 3.0 μg/kg/min. The doses that induced a larger than 3-fold increase in bleeding time were 33 μg/kg/min. Thus, the therapeutic index (TI) was ≥ 10. On the basis of these data, AZD1283 was progressed into human clinical trials as candidate drug.
Synonyms

AZD-1283; AZD1283; AZD 1283
Pathway

Angiogenesis
Target

PDE
Recptor

P2Y12
Research Area

Cardiovascular Disease
Indication

——

CAS Number

919351-41-0
Formula Weight

470.54
Molecular Formula

C23H26N4O5S
Purity

98%
Solubility

DMSO : 100 mg/mL. 212.52 mM;H2O : < 0.1 mg/mL
SMILES

CCOC(=O)c1c(nc(c(c1)C#N)N1CCC(CC1)C(=O)NS(=O)(=O)Cc1ccccc1)C
Chemical Name

ethyl 6-(4-((benzylsulfonyl)carbamoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate.

1. Bach P,et al. J Med Chem. 2013 Sep 12;56(17):7015-24.

Calculator

molnova catalog