CHDI-390576 ( CHDI390576 )

Catalog No. M12446 CAS No. 1629729-98-1

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

CHDI-390576
Note

Research use only, not for human use.
Brief Description

CHDI-390576 (CHDI390576) is a potent, cell permeable and CNS penetrant class IIa HDAC inhibitor.
Description

CHDI-390576 (CHDI390576) is a potent, cell permeable and CNS penetrant class IIa HDAC inhibitor with IC50 of 54/60/31/50 nM for HDAC4/5/7/9, respectively; displays >500-fold selectivity over class I HDAC/1/2/3 and 150-fold selectivity over HDAC8 and the class IIb HDAC6; CHDI-390576 was well-tolerated and showed no significant effect on passive observations, responses to manipulations, body weight, or body temperature in PK studies.
Synonyms

CHDI390576
Pathway

Cell Cycle/DNA Damage
Target

HDAC
Recptor

HDAC
Research Area

——
Indication

——

CAS Number

1629729-98-1
Formula Weight

391.33
Molecular Formula

C19H13F4N3O2
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(NO)C(C1=CC=CC=C1F)C2=CC=C(C3=NC=C(C(F)(F)F)C=N3)C=C2
Chemical Name

2-(2-fluorophenyl)-N-hydroxy-2-(4-(5-(trifluoromethyl)pyrimidin-2-yl)phenyl)acetamide

1. Luckhurst CA, et al. Bioorg Med Chem Lett. 2018 Nov 13. pii: S0960-894X(18)30858-8. doi: 10.1016/j.bmcl.2018.11.009.

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