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CHDI-390576
CAS No. 1629729-98-1
CHDI-390576 ( CHDI390576 )
Catalog No. M12446 CAS No. 1629729-98-1
CHDI-390576 (CHDI390576) is a potent, cell permeable and CNS penetrant class IIa HDAC inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameCHDI-390576
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NoteResearch use only, not for human use.
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Brief DescriptionCHDI-390576 (CHDI390576) is a potent, cell permeable and CNS penetrant class IIa HDAC inhibitor.
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DescriptionCHDI-390576 (CHDI390576) is a potent, cell permeable and CNS penetrant class IIa HDAC inhibitor with IC50 of 54/60/31/50 nM for HDAC4/5/7/9, respectively; displays >500-fold selectivity over class I HDAC/1/2/3 and 150-fold selectivity over HDAC8 and the class IIb HDAC6; CHDI-390576 was well-tolerated and showed no significant effect on passive observations, responses to manipulations, body weight, or body temperature in PK studies.
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SynonymsCHDI390576
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PathwayCell Cycle/DNA Damage
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TargetHDAC
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RecptorHDAC
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Research Area——
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Indication——
Chemical Information
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CAS Number1629729-98-1
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Formula Weight391.33
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Molecular FormulaC19H13F4N3O2
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(NO)C(C1=CC=CC=C1F)C2=CC=C(C3=NC=C(C(F)(F)F)C=N3)C=C2
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Chemical Name2-(2-fluorophenyl)-N-hydroxy-2-(4-(5-(trifluoromethyl)pyrimidin-2-yl)phenyl)acetamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Luckhurst CA, et al. Bioorg Med Chem Lett. 2018 Nov 13. pii: S0960-894X(18)30858-8. doi: 10.1016/j.bmcl.2018.11.009.
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