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CE-245677
CAS No. 717899-97-3
CE-245677( CE245677 )
Catalog No. M15745 CAS No. 717899-97-3
CE-245677 is a potent, selective, orally active, dual Tie2/Trk kinase inhibitor with IC50 of 4.7 nM, 1 nM for Tie2 and TrkA/B, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 71 | Get Quote |
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| 5MG | 110 | Get Quote |
|
| 10MG | 177 | Get Quote |
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| 25MG | 296 | Get Quote |
|
| 50MG | 410 | Get Quote |
|
| 100MG | 605 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameCE-245677
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NoteResearch use only, not for human use.
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Brief DescriptionCE-245677 is a potent, selective, orally active, dual Tie2/Trk kinase inhibitor with IC50 of 4.7 nM, 1 nM for Tie2 and TrkA/B, respectively.
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DescriptionCE-245677 is a potent, selective, orally active, dual Tie2/Trk kinase inhibitor with IC50 of 4.7 nM, 1 nM for Tie2 and TrkA/B, respectively; displays >100-fold selectivity against a panel of angiogenic receptor tyrosine kinases (e.g. KDR, PDGFR, FGFR).Pain Phase 1 Clinical.
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In VitroCE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50 of 4.7 and 1 nM, and displays >100x selectivity against a number of other angiogenic receptor tyrosine kinases, such as KDR, PDGFR, FGFR.
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In VivoCE-245677 shows good oral absorption in in vivo rat PK studies (F=80%).
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SynonymsCE245677
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PathwayTyrosine Kinase
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TargetAngiopoietin Receptor
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RecptorAngiopoietin Receptor
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Research AreaNeurological Disease
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IndicationPain
Chemical Information
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CAS Number717899-97-3
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Formula Weight513.379
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Molecular FormulaC24H22Cl2N6O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (243.48 mM)
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SMILESO=C(NC1=CC=C(Cl)C=C1Cl)NC2=CC(C(C3=CN(C(C)C)C4=NC=NC(N)=C43)=O)=CC=C2OC
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Chemical Name1-(5-(4-amino-7-isopropyl-7H-pyrrolo[2,3-d]-pyrimidine-5-carbonyl)-2-methoxyphenyl)-3-(2,4-dichlorophenyl)urea
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Susan LaGreca, et al. Identification of selective, orally active Tie2 kinase inhibitors and discovery of CE-245,677 and PF-371,989. AACR Annual Meeting-Apr 14-18, 2007.
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