CDK9-IN-1( —— )

Catalog No. M11724 CAS No. 1415559-43-1

COA

Datasheet

HNMR

HPLC

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Product Name

CDK9-IN-1
Note

Research use only, not for human use.
Brief Description

CDK9-IN-1 is a potent, selective CDK9 inhibitor with IC50 of 39 nM (CDK9/CycT1), >10-fold selectivity over CDK4 and >100-fold over CDK1/2/3/5/6/7, inhibits HIV-1 replication in cellular assays.
Description

CDK9-IN-1 is a potent, selective CDK9 inhibitor with IC50 of 39 nM (CDK9/CycT1), >10-fold selectivity over CDK4 and >100-fold over CDK1/2/3/5/6/7, inhibits HIV-1 replication in cellular assays.
In Vitro

CDK9-IN-1 is a potent CDK9 inhibitor that shows high activity against HIV-1 replication.
In Vivo

——
Synonyms

——
Pathway

Angiogenesis
Target

CDK
Recptor

CDK
Research Area

Infection
Indication

——

CAS Number

1415559-43-1
Formula Weight

499.541
Molecular Formula

C26H21N5O4S
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

CC1=C(C=C(C=C1)NC2=NC=NC(=C2)C3=CC(=CC=C3)N4C(=O)C5=CC=CC=C5C4=O)NS(=O)(=O)C
Chemical Name

N-(5-(6-(3-(1,3-dioxoisoindolin-2-yl)phenyl)pyrimidin-4-ylamino)-2-methylphenyl)methanesulfonamide

1. Németh G, et al. Curr Med Chem. 2011;18(3):342-58.

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