CDK12-IN-2
CAS No. 2244987-03-7
CDK12-IN-2 ( CDK12 inhibitor 2 )
Catalog No. M28236 CAS No. 2244987-03-7
CDK12-IN-2 is an effective and selective inhibitor of CDK12 with an IC50 of 52 nM, >100 μM, >10 μM and 16 μM for CDK12, CDK2, CDK7, and CDK9. CDK12-IN-2 can be used in studies about the function of CDK12.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 152 | Get Quote |
|
5MG | 260 | Get Quote |
|
10MG | 447 | Get Quote |
|
25MG | 714 | Get Quote |
|
50MG | 1017 | Get Quote |
|
100MG | 1368 | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameCDK12-IN-2
-
NoteResearch use only, not for human use.
-
Brief DescriptionCDK12-IN-2 is an effective and selective inhibitor of CDK12 with an IC50 of 52 nM, >100 μM, >10 μM and 16 μM for CDK12, CDK2, CDK7, and CDK9. CDK12-IN-2 can be used in studies about the function of CDK12.
-
DescriptionCDK12-IN-2 is an effective and selective inhibitor of CDK12 with an IC50 of 52 nM, >100 μM, >10 μM and 16 μM for CDK12, CDK2, CDK7, and CDK9. CDK12-IN-2 can be used in studies about the function of CDK12.(In Vitro):In SK-BR-3 cells, CDK12-IN-2 inhibits the phosphorylation of the CTD Ser2 with an IC50 of 185 nM. CDK12-IN-2 exhibits a growth inhibition with an IC50 of 0.8 μM. CDK12-IN-2 inhibits CDK12 in a time dependent manner with IC50s of 0.0078 μM, 0.042 μM, 0.057 μM,and 0.059 μM, for 0h, 1h, 2h and 5h.
-
SynonymsCDK12 inhibitor 2
-
PathwayAngiogenesis
-
TargetCDK
-
RecptorNF-κB;p38;Antifection;Trypanosoma cruzi;Leishmania tropica
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2244987-03-7
-
Formula Weight532.6
-
Molecular FormulaC32H32N6O2
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESN(C(NCC1=CC=CC=C1)=O)(C2=CC=C(C=C2)C3=CN(C)C(=O)C=C3)[C@H]4CC[C@H](NC5=CC=C(C#N)C=N5)CC4
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.da Rosa R, et al. Design and synthesis of a new series of 3,5-disubstituted isoxazoles active against Trypanosoma cruzi and Leishmania amazonensis. Eur J Med Chem. 2017 Mar 10;128:25-35.
molnova catalog
related products
-
1NM-PP1
1NM-PP1(PP1 Analog II) is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors(IC50=28 uM vSrc; 4.2 nM v-Src-as1 I338G).
-
Palbociclib (PD03329...
Palbociclib (PD0332991) Isethionate is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM.
-
BRD6989
A novel potent, selective CDK8 inhibitor with IC50 of 0.5 uM against recombinant Cyclin C/CDK8 complex; displays no activity against several CDKs involved in cell cycle including CDK19 (IC50>30 uM).