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CC214-1
CAS No. 1021920-32-0
CC214-1( —— )
Catalog No. M37621 CAS No. 1021920-32-0
CC214-1 is an mTOR inhibitor with potential anticancer activity, inhibits protein translation, and induces autophagy.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 296 | Get Quote |
|
| 5MG | 459 | Get Quote |
|
| 10MG | 657 | Get Quote |
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| 25MG | 994 | Get Quote |
|
| 50MG | 1371 | Get Quote |
|
| 100MG | 1773 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameCC214-1
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NoteResearch use only, not for human use.
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Brief DescriptionCC214-1 is an mTOR inhibitor with potential anticancer activity, inhibits protein translation, and induces autophagy.
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DescriptionCC214-1 is a potentially efficacious mTORinhibitor that induces autophagy ,with an IC50 is 0.002 μM. CC214-1 proved to be useful as an in vitro tool compound for the exploration of mTORkinase biology. CC214-1 can be used for Glioblastoma study.
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In VitroWestern Blot AnalysisCell Line:glioblastomaConcentration:0, 0.1, 1, 2, 5, 10 μM; 2 μM Incubation Time:8 h; 24 h Result:Inhibited mTORC1 signaling in all glioblastoma cell lines tested, potently suppressing rapamycin-resistant 4E-BP1 and mTORC2 signaling.Inhibited mTORC1-dependent 4E-BP1 and S6 phosphorylation in EGFRvIII-expressing glioblastoma cells, as well as blocked glioblastoma cells overexpressing wild-type EGFR.Immunofluorescence Cell Line:glioblastoma Concentration:2 μM, 5 μM Incubation Time:4 h; 0, 4, 12, 24, 48 h Result:Induced a transient expression of LC3B-II isoform and the conjugation of Atg12 to Atg5 indicative of the stimulation of the autophagy flux in U87EGFRvIII cell line. Massively lipidated LC3B-I to LC3B-II subtype and induces autophagy in GBM39 cells.Cell Cycle Analysis Cell Line:glioblastoma Concentration:0-10 μM Incubation Time:4 day Result:Induced TEE cells in CD4+ and CD8+ T cell subsets.
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In Vivo——
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Synonyms——
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PathwayAutophagy
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TargetAutophagy
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RecptorAutophagy | mTOR
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Research Area——
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Indication——
Chemical Information
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CAS Number1021920-32-0
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Formula Weight391.43
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Molecular FormulaC20H21N7O2
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C1NC2=NC=C(N=C2N1CCC3CCOCC3)C=4C=CC(=CC4)C5=NN=CN5
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Gini B, et al. The mTOR kinase inhibitors, CC214-1 and CC214-2, preferentially block the growth of EGFRvIII-activated glioblastomas. Clin Cancer Res. 2013 Oct 15;19(20):5722-32.?
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