CC-885

Research use only, not for human use.

CC-885 (CC 885, CC885) is a novel E3 ligase cereblon (CRBN) modulator with potent anti-tumour activity mediated through the degradation of GSPT1.

CC-885 (CC 885, CC885) is a novel E3 ligase cereblon (CRBN) modulator with potent anti-tumour activity mediated through the degradation of GSPT1; The anti-tumour activity of CC-885 is mediated through the cereblon-dependent ubiquitination and degradation of the translation termination factor GSPT1; promotes both the in vivo and in vitro ubiquitination of GSPT1 by cereblon and decreases the protein half-life of GSPT1.

CC 885;CC885

PROTACs

E3 Ligase Ligand

E3 Ligase Ligand

Cancer

——

1010100-07-8

440.90

C22H21ClN4O4

>98% (HPLC)

——

O=C(NCC1=CC2=C(C(N(C(CC3)C(NC3=O)=O)C2)=O)C=C1)NC4=CC=C(C)C(Cl)=C4

N-(3-chloro-4-methylphenyl)-N'-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-5-yl]methyl]-urea

(-20℃)

With Ice Pack

≥ 2 years