HaloPROTAC3

CAS No. 1799506-07-2

HaloPROTAC3( —— )

Catalog No. M34617 CAS No. 1799506-07-2

HaloPROTAC3 (HaloPROTAC-3) is a conjugate of ligands for E3 and 16-atom-length linker and a degrader of HaloTag fusion proteins.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 170 Get Quote
5MG 264 Get Quote
10MG 432 Get Quote
25MG 693 Get Quote
50MG 975 Get Quote
100MG 1287 Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    HaloPROTAC3
  • Note
    Research use only, not for human use.
  • Brief Description
    HaloPROTAC3 (HaloPROTAC-3) is a conjugate of ligands for E3 and 16-atom-length linker and a degrader of HaloTag fusion proteins.
  • Description
    VH285-PEG4-C4-Cl (HaloPROTAC 3) is a conjugate of ligands for E3 and 16-atom-length linker. The connector of linker is Halogen group. VH285-PEG4-C4-Cl incorporates the VH285 based VHL ligand and an alkyl/ether-based linker. VH285-PEG4-C4-Cl is a highly potent and efficacious degrader of GFP-HaloTag7 with a DC50 of 19 nM. VH285-PEG4-C4-Cl is able to induce 90 % degradation of GFP-Halotag at 625 nM. VH285-PEG4-C4-Cl binds to VHL with an IC50 of 0.54 μM.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    PROTACs
  • Target
    E3 Ligase Ligand
  • Recptor
    Ligand for E3 Ligase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1799506-07-2
  • Formula Weight
    799.42
  • Molecular Formula
    C41H55ClN4O8S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (125.09 mM; Ultrasonic )
  • SMILES
    [C@@H](C(=O)N1[C@H](C(NCC2=C(OCCOCCOCCOCCCCCCCl)C=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1)(C(C)C)N4C(=O)C=5C(C4)=CC=CC5
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Buckley DL, et al. HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins. ACS Chem Biol. 2015 Aug 21;10(8):1831-7.?
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