
CC-671
CAS No. 1618658-88-0
CC-671( CC671 | CC 671 )
Catalog No. M12372 CAS No. 1618658-88-0
CC-671 is a potent, selective, dual TTK (Mps1)/CLK2 inhibitor with IC50 of 5/3 nM, respectively.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 102 | In Stock |
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10MG | 170 | In Stock |
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25MG | 340 | In Stock |
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50MG | 511 | In Stock |
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100MG | 734 | In Stock |
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500MG | 1512 | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameCC-671
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NoteResearch use only, not for human use.
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Brief DescriptionCC-671 is a potent, selective, dual TTK (Mps1)/CLK2 inhibitor with IC50 of 5/3 nM, respectively.
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DescriptionCC-671 is a potent, selective, dual TTK (Mps1)/CLK2 inhibitor with IC50 of 5/3 nM, respectively; weakly inhibits DYRK3, DYRK1A, PHKG, DYRK1B, and CLK1 with IC50 of 0.1-0.3 uM, and displays excellent kinase selectivity (7/235 kinases > 80% inhibition at 3 uM); inhibits autophosphorylation of TTK at T686 or phosphorylation of SR protein 75 with IC50 of 0.057 and 0.549 uM in Cal-51 cells; demonstrates strong single agent in vivo efficacy in multiple TNBC xenograft models without significant body weight loss.Breast Cancer Preclinical.
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In VitroCC-671 (compound 23) is a dual TTK protein kinase/CDC2-like kinase (CLK2) inhibitor with IC50s of 0.005 and 0.006 μM for TTK and CLK2, respectively. HCT-116 cell lysates treated with CC-671 at 3 μM for 1 h demonstrates that only four kinases show cellular binding of 75% or more including CLK2, CAMKK2, PIP4K22, and JNK.
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In VivoCC-671 (compound 23) demonstrates significant tumor growth inhibition (TGI) ((vehicle -treated/vehicle) ×100%) of 71% at both 10 and 20 mg/kg on a every 3 days (q3d) dosing schedule. The body weight loss (BWL) in the CC-671 treated group (20 mg/kg ) is higher than in the 10 mg/kg group (17% vs 5%).
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SynonymsCC671 | CC 671
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PathwayCell Cycle/DNA Damage
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TargetMps1/TTK
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RecptorCLK2|TTK
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Research AreaCancer
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IndicationBreast Cancer
Chemical Information
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CAS Number1618658-88-0
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Formula Weight512.57
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Molecular FormulaC28H28N6O4
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Purity>98% (HPLC)
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SolubilityDMSO: 60 mg/mL ( < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESO=C(NC)C1=CC=C(NC2=NC(OC3CCCC3)=C4C(NC=C4C5=CC=C6N=C(C)OC6=C5)=N2)C(OC)=C1
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Chemical Name4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7H-pyrrolo-[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-N-methylbenzamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Riggs JR, et al. J Med Chem. 2017 Nov 9;60(21):8989-9002.
molnova catalog



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