CC-671

CAS No. 1618658-88-0

CC-671( CC671 | CC 671 )

Catalog No. M12372 CAS No. 1618658-88-0

CC-671 is a potent, selective, dual TTK (Mps1)/CLK2 inhibitor with IC50 of 5/3 nM, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 102 In Stock
10MG 170 In Stock
25MG 340 In Stock
50MG 511 In Stock
100MG 734 In Stock
500MG 1512 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    CC-671
  • Note
    Research use only, not for human use.
  • Brief Description
    CC-671 is a potent, selective, dual TTK (Mps1)/CLK2 inhibitor with IC50 of 5/3 nM, respectively.
  • Description
    CC-671 is a potent, selective, dual TTK (Mps1)/CLK2 inhibitor with IC50 of 5/3 nM, respectively; weakly inhibits DYRK3, DYRK1A, PHKG, DYRK1B, and CLK1 with IC50 of 0.1-0.3 uM, and displays excellent kinase selectivity (7/235 kinases > 80% inhibition at 3 uM); inhibits autophosphorylation of TTK at T686 or phosphorylation of SR protein 75 with IC50 of 0.057 and 0.549 uM in Cal-51 cells; demonstrates strong single agent in vivo efficacy in multiple TNBC xenograft models without significant body weight loss.Breast Cancer Preclinical.
  • In Vitro
    CC-671 (compound 23) is a dual TTK protein kinase/CDC2-like kinase (CLK2) inhibitor with IC50s of 0.005 and 0.006 μM for TTK and CLK2, respectively. HCT-116 cell lysates treated with CC-671 at 3 μM for 1 h demonstrates that only four kinases show cellular binding of 75% or more including CLK2, CAMKK2, PIP4K22, and JNK.
  • In Vivo
    CC-671 (compound 23) demonstrates significant tumor growth inhibition (TGI) ((vehicle -treated/vehicle) ×100%) of 71% at both 10 and 20 mg/kg on a every 3 days (q3d) dosing schedule. The body weight loss (BWL) in the CC-671 treated group (20 mg/kg ) is higher than in the 10 mg/kg group (17% vs 5%).
  • Synonyms
    CC671 | CC 671
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Mps1/TTK
  • Recptor
    CLK2|TTK
  • Research Area
    Cancer
  • Indication
    Breast Cancer

Chemical Information

  • CAS Number
    1618658-88-0
  • Formula Weight
    512.57
  • Molecular Formula
    C28H28N6O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 60 mg/mL ( < 1 mg/ml refers to the product slightly soluble or insoluble )
  • SMILES
    O=C(NC)C1=CC=C(NC2=NC(OC3CCCC3)=C4C(NC=C4C5=CC=C6N=C(C)OC6=C5)=N2)C(OC)=C1
  • Chemical Name
    4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7H-pyrrolo-[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-N-methylbenzamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Riggs JR, et al. J Med Chem. 2017 Nov 9;60(21):8989-9002.
molnova catalog
related products
  • CC-671

    CC-671 is a potent, selective, dual TTK (Mps1)/CLK2 inhibitor with IC50 of 5/3 nM, respectively.

  • Empesertib (BAY 1161...

    BAY 1161909 is a potent Mps1 inhibitor, with an IC50 of < 1 nM.