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CB-002
CAS No. 61034-15-9
CB-002( —— )
Catalog No. M15293 CAS No. 61034-15-9
A novel small molecule that restores p53 function in mutant p53-expressing colorectal cancer cells without toxicity to normal human fibroblasts.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameCB-002
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NoteResearch use only, not for human use.
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Brief DescriptionA novel small molecule that restores p53 function in mutant p53-expressing colorectal cancer cells without toxicity to normal human fibroblasts.
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DescriptionA novel small molecule that restores p53 function in mutant p53-expressing colorectal cancer cells without toxicity to normal human fibroblasts; increases expression of endogenous p53 target genes NOXA, DR5, and p21 and cell death; decreases the stability of mutant p53 in RXF393 cancer cells and an exogenously expressed R175H p53 mutant in HCT116 p53-null cells.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayApoptosis
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TargetMDM2-p53
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RecptorMDM2-p53
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Research Area——
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Indication——
Chemical Information
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CAS Number61034-15-9
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Formula Weight271.28
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Molecular FormulaC13H13N5O2
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Purity>98% (HPLC)
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Solubility——
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SMILESCN1C2=C(C(=O)N(C1=O)C)NC(=N2)NC3=CC=CC=C3
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Chemical Name8-Anilino-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Hernandez-Borrero LJ, et al. Cell Cycle. 2017 Jul 27:0. doi: 10.1080/15384101.2017.1346762.
2. Richardson C, et al. Cell Cycle. 2017 Jul 27:0. doi: 10.1080/15384101.2017.1356514.
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