Cart
sales@molnova.com
CAY10602
CAS No. 374922-43-7
CAY10602( CAY10602 | CAY-10602 | CAY 10602 )
Catalog No. M18489 CAS No. 374922-43-7
CAY10602 is a SIRT1 activator. CAY10602 was derived from high throughput screening for compounds that increase SIRT1-mediated deacetylation of a SIRT1-specific substrate.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 42 | In Stock |
|
| 10MG | 51 | In Stock |
|
| 25MG | 87 | In Stock |
|
| 50MG | 165 | In Stock |
|
| 100MG | 293 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameCAY10602
-
NoteResearch use only, not for human use.
-
Brief DescriptionCAY10602 is a SIRT1 activator. CAY10602 was derived from high throughput screening for compounds that increase SIRT1-mediated deacetylation of a SIRT1-specific substrate.
-
DescriptionCAY10602 is a SIRT1 activator. CAY10602 was derived from high throughput screening for compounds that increase SIRT1-mediated deacetylation of a SIRT1-specific substrate. Functional assays show that CAY10602 dose-dependently suppresses the NF-κB-dependent induction of TNF-α by lipopolysaccharide in THP-1 cells, with approximately 75% inhibition achieved at 60 μM, without cytotoxicity.
-
In VitroCompounds (including CAY10602/compound 1) with SIRT1-activating properties have a significant effect on fat mobilization in differentiated adipocytes, and these compounds (including CAY10602) have antiobesity and/or antidiabetic properties. Compounds (including CAY10602) with SIRT1 activating potential exert strong suppression of TNF-α release at concentrations between 20 and 60 μM.
-
In Vivo——
-
SynonymsCAY10602 | CAY-10602 | CAY 10602
-
PathwayOthers
-
TargetOther Targets
-
RecptorSIRT1
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number374922-43-7
-
Formula Weight418.44
-
Molecular FormulaC22H15FN4O2S
-
Purity>98% (HPLC)
-
SolubilityDMSO : 100 mg/mL 238.98 mM
-
SMILESFc1ccc(cc1)n1c2nc3ccccc3nc2c(c1N)S(=O)(=O)c1ccccc1
-
Chemical Name1-(4-fluorophenyl)-3-(phenylsulfonyl)-1H-pyrrolo[2,3-b]quinoxalin-2-amine
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. H?ppner S, et al. Fragmentation studies of SIRT1-activating drugs and their detection in human plasma for doping control purposes. Rapid Commun Mass Spectrom. 2013 Jan 15;27(1):35-50.
molnova catalog
related products
-
Thalidomide-O-amido-...
Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride incorporates an E3 ligase ligand and a linker.
-
TMN355
TMN355 is a potent chemical inhibitor of cyclophilin A and reduces foam cell formation and cytokine secretion,and is used for atherosclerosis. Silencing cyclophilin A in THP-1 cells and human monocytes using siRNA or chemical inhibitor, TMN355 resulted in decrease in lipid uptake by 65-75% even after exposure to oxidized LDL.
-
CB-5339
p97-IN-1 is a potent inhibitor of p97 with an IC 50 <30 nM .
