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CAY10602

CAS No. 374922-43-7

CAY10602( CAY10602 | CAY-10602 | CAY 10602 )

Catalog No. M18489 CAS No. 374922-43-7

CAY10602 is a SIRT1 activator. CAY10602 was derived from high throughput screening for compounds that increase SIRT1-mediated deacetylation of a SIRT1-specific substrate.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    CAY10602
  • Note
    Research use only, not for human use.
  • Brief Description
    CAY10602 is a SIRT1 activator. CAY10602 was derived from high throughput screening for compounds that increase SIRT1-mediated deacetylation of a SIRT1-specific substrate.
  • Description
    CAY10602 is a SIRT1 activator. CAY10602 was derived from high throughput screening for compounds that increase SIRT1-mediated deacetylation of a SIRT1-specific substrate. Functional assays show that CAY10602 dose-dependently suppresses the NF-κB-dependent induction of TNF-α by lipopolysaccharide in THP-1 cells, with approximately 75% inhibition achieved at 60 μM, without cytotoxicity.
  • In Vitro
    Compounds (including CAY10602/compound 1) with SIRT1-activating properties have a significant effect on fat mobilization in differentiated adipocytes, and these compounds (including CAY10602) have antiobesity and/or antidiabetic properties. Compounds (including CAY10602) with SIRT1 activating potential exert strong suppression of TNF-α release at concentrations between 20 and 60 μM.
  • In Vivo
    ——
  • Synonyms
    CAY10602 | CAY-10602 | CAY 10602
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    SIRT1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    374922-43-7
  • Formula Weight
    418.44
  • Molecular Formula
    C22H15FN4O2S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 100 mg/mL 238.98 mM
  • SMILES
    Fc1ccc(cc1)n1c2nc3ccccc3nc2c(c1N)S(=O)(=O)c1ccccc1
  • Chemical Name
    1-(4-fluorophenyl)-3-(phenylsulfonyl)-1H-pyrrolo[2,3-b]quinoxalin-2-amine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. H?ppner S, et al. Fragmentation studies of SIRT1-activating drugs and their detection in human plasma for doping control purposes. Rapid Commun Mass Spectrom. 2013 Jan 15;27(1):35-50.
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